{"doi":"10.1021/jm0256023","title":"A Novel N-Terminal Cyclic Dynorphin A Analogue<i>cyclo<sup>N,5</sup></i>[Trp<sup>3</sup>,Trp<sup>4</sup>,Glu<sup>5</sup>] Dynorphin A-(1−11)NH<sub>2</sub>That Lacks the Basic N-Terminus","abstract":null,"journal":"Journal of Medicinal Chemistry","year":2003,"id":665568,"datarank":0.5050943744979712,"base_score":3.367295829986474,"endowment":3.367295829986474,"self_citation_contribution":0.5050943744979712,"citation_network_contribution":0.0,"self_endowment_contribution":0.5050943744979712,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":373612,"name":"Thomas F. Murray","orcid":"0000-0001-8521-4507","position":1,"is_corresponding":false},{"id":373613,"name":"Jane V. Aldrich","orcid":"0000-0002-7954-9850","position":2,"is_corresponding":false},{"id":1738002,"name":"Balvinder S. Vig","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A Novel N-Terminal Cyclic Dynorphin A Analogue<i>cyclo<sup>N,5</sup></i>[Trp<sup>3</sup>,Trp<sup>4</sup>,Glu<sup>5</sup>] Dynorphin A-(1−11)NH<sub>2</sub>That Lacks the Basic N-Terminus","abstract":"A novel N-terminal-to-side chain cyclic dynorphin A analogue lacking the basic N-terminus was designed based on Ac[Lys(2),Trp(3),Trp(4),d-Ala(8)]dynorphin A-(1-11)NH(2) (Wan et al. J. Med. Chem. 1999, 42, 3011-3013). cyclo(N,5)[Trp(3),Trp(4),Glu(5)]dynorphin A-(1-11)NH(2) showed similar kappa opioid receptor affinity (K(i) = 27 nM) and selectivity (K(i) ratio (kappa/mu/delta) = 1/12/330) to the linear peptide and antagonized dynorphin A-(1-13)NH(2) at kappa opioid receptors. This is the first opioid peptide cyclized through the N-terminus that retains high opioid receptor affinity.","is_dataset_classified":null,"base_score":3.367295829986474,"endowment":3.367295829986474,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12672226","pmcid":null,"openalex_id":"https://openalex.org/W2313401199","authors":[],"funders":[{"funder_name":"NIDA NIH HHS","grant_id":"DA05195","title":null}],"total_grants":1,"fwci":0.3033,"citation_percentile":0.45927776,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2013,"count":1},{"year":2015,"count":3},{"year":2016,"count":2},{"year":2017,"count":3},{"year":2019,"count":1},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":1}],"oa_status":"green","license":null,"oa_locations":[{"url":"https://doi.org/10.7270/q22f7mtk","host_type":"repository"},{"url":"https://doi.org/10.7270/q22f7mtk","host_type":"repository"},{"url":"https://pubs.acs.org/doi/pdf/10.1021/jm0256023","host_type":"publisher"},{"url":"https://doi.org/10.1021/jm0256023","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12672226","host_type":"repository"}],"fields_of_study":["Neuropeptides and Animal Physiology","Receptor Mechanisms and Signaling","Pharmacological Receptor Mechanisms and Effects","Animals","CHO Cells","Cricetinae","Cyclic AMP","Dynorphins","Ligands","Peptides, Cyclic","Receptors, Opioid, kappa"],"mesh_terms":["Cyclic AMP","Animals","Dynorphins","Cricetinae","Ligands","Peptides, Cyclic","CHO Cells","Receptors, Opioid, kappa"],"keywords":["Dynorphin","Chemistry","Dynorphin A","Opioid peptide","Stereochemistry","κ-opioid receptor","Peptide","Receptor","Opioid","Biochemistry"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-13T11:32:59.171760Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}