{"doi":"10.1021/jm00398a018","title":"Synthesis of arginine-vasopressins, modified in positions 1 and 2, as antagonists of the vasopressor response to the parent hormone","abstract":null,"journal":"Journal of Medicinal Chemistry","year":1988,"id":646300,"datarank":0.5606504427425053,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"self_citation_contribution":0.5606504427425053,"citation_network_contribution":0.0,"self_endowment_contribution":0.5606504427425053,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1683296,"name":"Piotr Rekowski","orcid":null,"position":1,"is_corresponding":false},{"id":1683297,"name":"Gotfryd Kupryszewski","orcid":null,"position":2,"is_corresponding":false},{"id":1683299,"name":"Per Melin","orcid":null,"position":3,"is_corresponding":false},{"id":1683300,"name":"Ulf Ragnarsson","orcid":null,"position":4,"is_corresponding":false},{"id":1683295,"name":"Bernard Lammek","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Synthesis of arginine-vasopressins, modified in positions 1 and 2, as antagonists of the vasopressor response to the parent hormone","abstract":"In an attempt to determine some of the structural features in position 1 that account for antivasopressor activity, eight new 1-(beta, beta-dialkyl-substituted) analogues of 1-(3-mercaptopropanoic acid)-8-arginine-vasopressin and 1-(3-mercaptopropanoic acid)-2-O-methyltyrosine-8-arginine-vasopressin have been designed and synthesized. The protected precursors required for these peptides were obtained by a combination of solid-phase and solutions methods. Some of the reported analogues, namely 1-(1-mercapto-4-methylcyclohexaneacetic acid)-8-arginine-vasopressin, 1-(1-mercapto-4-methylcyclohexaneacetic acid)-2-O-methyltryosine-8-arginine-vasopressin, 1-(4-tert-butyl-1-mercaptocyclohexaneacetic acid)-2-O-methyltyrosine-8-arginine- vasopressin, 1-(1-mercapto-4-phenylcyclohexaneacetic acid)-8-arginine-vasopressin and 1-(1-mercapto-4-phenylcyclohexaneacetic acid)-2-O-methyltyrosine-8-arginine- vasopressin, are among the most potent and selective antagonists of the vasopressor response to arginine-vasopressin reported to date.","is_dataset_classified":null,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"3346876","pmcid":null,"openalex_id":"https://openalex.org/W2008487521","authors":[],"funders":[],"total_grants":0,"fwci":2.0743,"citation_percentile":0.85748048,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2024,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/jm00398a018","host_type":"publisher"},{"url":"https://doi.org/10.1021/jm00398a018","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/3346876","host_type":"repository"}],"fields_of_study":["Neuroendocrine regulation and behavior","Chemical Reaction Mechanisms","Animals","Arginine Vasopressin","Blood Pressure","Chemical Phenomena","Chemistry, Physical","Female","Rats","Rats, Inbred Strains"],"mesh_terms":["Animals","Arginine Vasopressin","Blood Pressure","Chemistry, Physical","Female","Rats, Inbred Strains","Rats","Chemical Phenomena"],"keywords":["Chemistry","Arginine","Pharmacology","Hormone","Biochemistry","Amino acid","Medicine"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T12:31:36.034287Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}