{"doi":"10.1021/jasms.5c00222","title":"Development and Modification of Ion Mobility Mass Spectrometry Instrumentation for Enhanced Analysis of Biological Molecules","abstract":"Ion mobility separates ion in the gas phase based on rotationally averaged cross section, a parameter often correlated with size, providing a versatile measurement strategy when integrated with mass spectrometry. The rapid growth in the field of ion mobility mass spectrometry has been catalyzed by numerous innovative advances in instrumentation that have improved resolution, sensitivity, and the ability to measure collision cross sections. These advances in ion mobility instrumentation and methods have been translated into many applications in the fields of metabolomics, lipidomics, proteomics, and structural biology. This Perspective focuses on developments in ion mobility instrumentation, spanning the impressive capabilities of commercial platforms to customized designs and modifications that establish new benchmarks at the frontiers of ion mobility mass spectrometry.","journal":"Journal of the American Society for Mass Spectrometry","year":2025,"id":535195,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9512,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":215664,"name":"Jennifer S. Brodbelt","orcid":"0000-0003-3207-0217","position":1,"is_corresponding":false},{"id":1083697,"name":"Jamie P. Butalewicz","orcid":"0009-0004-6954-8450","position":0,"is_corresponding":true}],"reference_count":221,"raw_metadata":null,"created_at":"2026-07-19T02:51:56.297114Z","pmid":"41147493","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}