{"doi":"10.1021/jasms.1c00319","title":"Optimized C-Trap Timing of an Orbitrap 240 Mass Spectrometer for High-Throughput Screening and Native MS by IR-MALDESI","abstract":null,"journal":"Journal of the American Society for Mass Spectrometry","year":2022,"id":632753,"datarank":0.5416376868966337,"base_score":3.6109179126442243,"endowment":3.6109179126442243,"self_citation_contribution":0.5416376868966337,"citation_network_contribution":0.0,"self_endowment_contribution":0.5416376868966337,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":36,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1640274,"name":"Michael C. Bagley","orcid":null,"position":1,"is_corresponding":false},{"id":726832,"name":"Kenneth P. Garrard","orcid":"0000-0002-0654-4776","position":2,"is_corresponding":false},{"id":1640275,"name":"Jan-Peter Hauschild","orcid":null,"position":3,"is_corresponding":false},{"id":395725,"name":"Fan Pu","orcid":"0000-0003-4246-2556","position":4,"is_corresponding":false},{"id":960367,"name":"Nathaniel L. Elsen","orcid":"0000-0003-1192-7242","position":5,"is_corresponding":false},{"id":600697,"name":"Jon D. Williams","orcid":"0000-0001-9873-4165","position":6,"is_corresponding":false},{"id":448808,"name":"David C. Muddiman","orcid":"0000-0003-2216-499X","position":7,"is_corresponding":false},{"id":864689,"name":"Kevan T. Knizner","orcid":"0000-0002-8846-3135","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Optimized C-Trap Timing of an Orbitrap 240 Mass Spectrometer for High-Throughput Screening and Native MS by IR-MALDESI","abstract":"Infrared matrix-assisted laser desorption ionization (IR-MALDESI) is a hybrid mass spectrometry ionization source that combines the benefits of electrospray ionization (ESI) and matrix-assisted laser desorption ionization (MALDI) making it a great analytical tool for high-throughput screening (HTS) analyses. IR-MALDESI is coupled to an Orbitrap Exploris 240 mass spectrometer that utilizes a bent quadrupole (C-trap) to inject accumulated ions into the high-field Orbitrap mass analyzer. Here, we present a study on the optimized C-trap timing for HTS analyses by IR-MALDESI mass spectrometry. The timing between initial ion generation and the C-trap opening time was optimized to reduce unnecessary ambient ion accumulation in the mass spectrometer. The time in which the C-trap was held open, the ion accumulation time, was further optimized to maximize the accumulation of analyte ions generated using IR-MALDESI. The resulting C-trap opening scheme benefits small-molecule HTS analyses by IR-MALDESI by maximizing target ion abundances, minimizing ambient ion abundances, and minimizing the total analysis time per sample. The proposed C-trap timing scheme for HTS does not translate to large molecules; a NIST monoclonal antibody standard reference material was analyzed to demonstrate that larger analytes require longer ion accumulation times and that IR-MALDESI can measure intact antibodies in their native state.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35073091","pmcid":"PMC9944060","openalex_id":null,"authors":[],"funders":[{"funder_name":"National Institute of General Medical Sciences","grant_id":"R01GM087964","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01GM087964-04","title":"Development and Application of New Ionization Methods for Biological Mass Spectro"},{"funder_name":"AbbVie","grant_id":"","title":null}],"total_grants":3,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"STM Policy #29","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9944060","host_type":"repository"},{"url":"https://pubs.acs.org/doi/pdf/10.1021/jasms.1c00319","host_type":"publisher"},{"url":"https://doi.org/10.1021/jasms.1c00319","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/35073091","host_type":""}],"fields_of_study":["0301 basic medicine","03 medical and health sciences","01 natural sciences","0104 chemical sciences"],"mesh_terms":[],"keywords":["High-throughput screening","Orbitrap Mass Spectrometer","Ir-maldesi","C-trap"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T10:16:53.161677Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}