{"doi":"10.1021/jacs.5c19654","title":"Enantioselective Total Synthesis of (+)-Fusicoccadiene via Photocatalytic Polyene Isomerization","abstract":"The fusicoccane diterpenes have amassed interest for their intricate 5-8-5 tricyclic framework and ability to interface with diverse signaling proteins. Herein, we report an enantioselective synthetic platform for the rapid assembly of fusicoccanes where the 5-8-5 motif is prepared via valence bond isomerization of a polyene precursor. A series of regio- and stereoselective modifications to the periphery of this substructure provides entry to diverse fusicoccane congeners. The utility of this strategy is demonstrated with a concise total synthesis of (+)-fusicoccadiene.","journal":"Journal of the American Chemical Society","year":2025,"id":537770,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9474,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1175858,"name":"Tyler Weinhold","orcid":null,"position":1,"is_corresponding":false},{"id":1424477,"name":"Jacqueline Pinkerton","orcid":null,"position":2,"is_corresponding":false},{"id":907912,"name":"James A. Law","orcid":"0000-0002-8802-5012","position":3,"is_corresponding":false},{"id":588682,"name":"James H. Frederich","orcid":"0000-0003-2077-4436","position":4,"is_corresponding":false},{"id":908476,"name":"Vitalii S. Basistyi","orcid":null,"position":0,"is_corresponding":true}],"reference_count":39,"raw_metadata":null,"created_at":"2026-07-19T02:52:16.891390Z","pmid":"41472317","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}