{"doi":"10.1021/jacs.5c17640","title":"Short, Enantioselective Total Synthesis of (+)-Ineleganolide","abstract":"High Resolution Image Download MS PowerPoint Slide Owing to their distinctive polycyclic architectures and promising bioactivities, the large family of furanocembranoid natural products continues to attract significant attention from the synthetic community. Herein, we present a 10-step total synthesis of (+)-ineleganolide, a highly oxidized norcembranoid natural product featuring a synthetically challenging caged pentacyclic framework. An interesting trans -selective photochemical [2 + 2] cycloaddition involving an unusual α,β -unsaturated tricarbonyl chromophore was used to generate a strained cyclobutanol which underwent a C–C bond cleavage cascade when exposed to Brønsted acid. Through this sequence, the ineleganolide core polycycle was generated in only six steps from commercially available materials. This strategy provides a conceptually new abiotic blueprint for this fascinating family of diterpenes.","journal":"Journal of the American Chemical Society","year":2025,"id":527590,"datarank":0.7971192576439371,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.5891751034759535,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.5891751034759535,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":3,"citers_with_citation_signal":1,"citers_with_endowment":1,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.946,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1404915,"name":"Aikaterini Gorou","orcid":null,"position":1,"is_corresponding":false},{"id":1404393,"name":"Danny Huang","orcid":"0000-0001-9542-5092","position":2,"is_corresponding":false},{"id":263054,"name":"Thomas J. Maimone","orcid":"0000-0001-5823-692X","position":3,"is_corresponding":false},{"id":877187,"name":"Kuan Yu","orcid":"0009-0001-7605-7033","position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:50:39.280101Z","pmid":"41271198","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}