{"doi":"10.1021/jacs.5c15963","title":"Enantioselective C–H Activation for the Construction of Chiral Tertiary Fluorides via Migrative Carbofluorination","abstract":"Construction of α-chiral centers via enantioselective C(sp 3 )–H activation of the isobutyric acid scaffold has emerged as a new chiral technology. However, this approach has not been compatible with the presence of α-fluorine, which prevented the access to fluorine-bearing α-chiral centers which are highly valuable in drug discovery. Here, we report a palladium-catalyzed asymmetric β-C(sp 3 )–H activation of the gem -dimethyl motif, followed by a dyotropic rearrangement that installs fluoro and aryl groups at the α- and β-positions, respectively. Using a bifunctional chiral monoprotected amino sulfonamide (MPASA) ligand, this method affords chiral tertiary fluorides with high reactivity and enantioselectivity, enabling access to desirable motifs in drug discovery.","journal":"Journal of the American Chemical Society","year":2025,"id":529596,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9428,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":876367,"name":"Yuxin Ouyang","orcid":"0000-0001-5453-513X","position":1,"is_corresponding":false},{"id":1225964,"name":"Tao Zhang","orcid":"0009-0002-1668-0453","position":2,"is_corresponding":false},{"id":321507,"name":"Jin‐Quan Yu","orcid":"0000-0003-3560-5774","position":3,"is_corresponding":false},{"id":1408892,"name":"Zi-Yu Zhang","orcid":null,"position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-19T02:50:56.971987Z","pmid":"41422543","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}