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Key features of the synthesis include the construction of the 2-aza-3-oxobicyclo[2.2.2]octene core via an intramolecular pyridone Diels–Alder reaction and a Zr-mediated bisamide reduction that induces a tandem N, O -acetal forming cascade reaction.","is_dataset_classified":null,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"datacite_reuse_total":5,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40681163","pmcid":null,"openalex_id":"https://openalex.org/W4412520868","authors":[],"funders":[{"funder_name":"Division of Chemistry","grant_id":"CHE-1764240","title":null},{"funder_name":"Welch Foundation","grant_id":"AA-006","title":null},{"funder_name":"Cancer Prevention and Research Institute of Texas","grant_id":"R1309","title":null},{"funder_name":"National Institute of General Medical Sciences","grant_id":"R01GM136759","title":null},{"funder_name":"Baylor University","grant_id":"","title":null}],"total_grants":5,"fwci":0.9428,"citation_percentile":0.7510582,"influential_citations":0,"citation_trend":[{"year":2025,"count":1}],"oa_status":"green","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","oa_locations":[{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12315839/","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12315839/","host_type":"repository"},{"url":"https://pubs.acs.org/doi/pdf/10.1021/jacs.5c07636","host_type":"publisher"},{"url":"https://doi.org/10.1021/jacs.5c07636","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40681163","host_type":"repository"}],"fields_of_study":["Alkaloids: synthesis and pharmacology","Asymmetric Synthesis and Catalysis","Chemical synthesis and alkaloids","Bacillus subtilis","Secologanin Tryptamine Alkaloids","Molecular Structure","Stereoisomerism"],"mesh_terms":["Bacillus subtilis","Stereoisomerism","Molecular Structure","Secologanin Tryptamine Alkaloids"],"keywords":["Chemistry","Total synthesis","Moiety","Epimer","Stereochemistry","Acetal","Intramolecular force","Indole test","Bicyclic molecule","Glycosylation","Benzopyran"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[{"doi":"10.5517/ccdc.csd.cc2kqt15","title":"CCDC 2375407: Experimental Crystal Structure Determination","publisher":"Cambridge Crystallographic Data Centre","resource_type":"Dataset"},{"doi":"10.5517/ccdc.csd.cc2ml65m","title":"CCDC 2430560: Experimental Crystal Structure Determination","publisher":"Cambridge Crystallographic Data Centre","resource_type":"Dataset"},{"doi":"10.5517/ccdc.csd.cc2ml64l","title":"CCDC 2430559: Experimental Crystal Structure Determination","publisher":"Cambridge Crystallographic Data Centre","resource_type":"Dataset"},{"doi":"10.5517/ccdc.csd.cc2kqj50","title":"CCDC 2375132: Experimental Crystal Structure Determination","publisher":"Cambridge Crystallographic Data Centre","resource_type":"Dataset"},{"doi":"10.5517/ccdc.csd.cc2kqjjc","title":"CCDC 2375143: Experimental Crystal Structure Determination","publisher":"Cambridge Crystallographic Data Centre","resource_type":"Dataset"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T12:21:59.144808Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}