{"doi":"10.1021/jacs.5c07227","title":"Enantiocontrolled Azetidine Library Synthesis via Strain-Release Functionalization of 1-Azabicyclobutanes","abstract":"A simple, modular, and programmable approach to access complex stereopure azetidines through strain-release functionalization is disclosed. The synthetic methods developed enable the parallel synthesis of stereodefined azetidines that would be otherwise laborious to produce. Given the privileged nature of these structures, a set of stereoprobes for use in activity-based protein profiling was prepared and evaluated, revealing proteins in human cancer cells, which were liganded with clear stereo- and chemo-selectivity.","journal":"Journal of the American Chemical Society","year":2025,"id":510832,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.948,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1040567,"name":"Molhm Nassir","orcid":"0000-0002-4996-2249","position":1,"is_corresponding":false},{"id":1246246,"name":"Hayden A. Sharma","orcid":"0000-0003-3894-9118","position":2,"is_corresponding":false},{"id":1232964,"name":"Nathanyal J. Truax","orcid":null,"position":3,"is_corresponding":false},{"id":1132084,"name":"Nicholas Raheja","orcid":null,"position":4,"is_corresponding":false},{"id":1331678,"name":"Ty M. Thompson","orcid":null,"position":5,"is_corresponding":false},{"id":854692,"name":"Tamara El‐Hayek Ewing","orcid":"0000-0001-8974-2462","position":6,"is_corresponding":false},{"id":443636,"name":"Bruno Melillo","orcid":"0000-0002-9708-5287","position":7,"is_corresponding":false},{"id":236419,"name":"Benjamin F. Cravatt","orcid":"0000-0001-5330-3492","position":8,"is_corresponding":false},{"id":264499,"name":"Phil S. Baran","orcid":"0000-0001-9193-9053","position":9,"is_corresponding":false},{"id":705497,"name":"Michael Bielecki","orcid":null,"position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-19T02:47:50.575618Z","pmid":"40501015","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}