{"doi":"10.1021/jacs.5c03379","title":"3,6-Anhydrogalactal as a Single-Addition Monomer for Chain-End Functionalization of Metathesis Polymers","abstract":"Controlling the structure and reactivity of the chain-end group is a central objective in modern polymer chemistry. Here we introduce 3,6-anhydrogalactal as a single-addition monomer that enables efficient and versatile chain-end functionalization of metathesis polymers. Readily synthesized from biomass-derived galactal, 3,6-anhydrogalactal exhibits excellent single-addition reactivity, allowing precise chain-end modifications even when introduced simultaneously with the propagating monomer. Theoretical calculations provide mechanistic insights into the unique reactivities governing its single-addition behavior. Its broad functional group compatibility facilitates diverse applications, including block copolymer synthesis, polymer-polymer coupling, and bioconjugation, demonstrating significant potential for advancing polymer materials and bioconjugation strategies.","journal":"Journal of the American Chemical Society","year":2025,"id":523333,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9506,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1079898,"name":"Quan Pham","orcid":"0009-0001-9559-7772","position":1,"is_corresponding":false},{"id":866379,"name":"Gavin J. Giardino","orcid":"0000-0001-9382-2967","position":2,"is_corresponding":false},{"id":117143,"name":"Abhishek Chatterjee","orcid":"0000-0002-6231-5302","position":3,"is_corresponding":false},{"id":325437,"name":"Jia Niu","orcid":"0000-0002-5622-6362","position":4,"is_corresponding":false},{"id":1090586,"name":"Zefeng Zhou","orcid":"0009-0003-4713-9923","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-19T02:50:03.004175Z","pmid":"40346725","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}