{"doi":"10.1021/jacs.5c03235","title":"Dual-Channel Phosphorescence Ratiometry and Phosphorescence Lifetime Imaging of Mitochondria-Specific Methionine Sulfoxide Reductase Activity","abstract":null,"journal":"Journal of the American Chemical Society","year":2025,"id":636356,"datarank":0.4943755299006494,"base_score":3.295836866004329,"endowment":3.295836866004329,"self_citation_contribution":0.4943755299006494,"citation_network_contribution":0.0,"self_endowment_contribution":0.4943755299006494,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":26,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1494714,"name":"Chen Chen","orcid":"0000-0003-3974-2952","position":1,"is_corresponding":false},{"id":1219587,"name":"Yang Tian","orcid":"0000-0001-8850-0349","position":2,"is_corresponding":false},{"id":1651542,"name":"Qi-Wei Zhang","orcid":"0000-0003-1527-0559","position":3,"is_corresponding":false},{"id":320818,"name":"Xuewei Wang","orcid":"0000-0002-1375-7358","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Dual-Channel Phosphorescence Ratiometry and Phosphorescence Lifetime Imaging of Mitochondria-Specific Methionine Sulfoxide Reductase Activity","abstract":"Methionine sulfoxide reductases (Msrs) are essential for preserving redox homeostasis in the nervous system, with dysregulation implicated in Alzheimer's disease (AD). Conventional fluorescence-based assays for Msrs activity sensing are hampered by background interference, limited sensitivity, and inadequate quantification. This work introduces a novel supramolecular probe exhibiting redox-responsive dual-channel room-temperature phosphorescence (RTP) in aqueous media on a microsecond time scale. Upon reduction by Msrs, the probe transitions from its oxidized to reduced state, manifested by a red-shifted phosphorescence emission and extended lifetime in the microsecond range, which enables precise quantification of mitochondria-targeted Msrs activity via phosphorescence ratiometry and phosphorescence lifetime imaging (PLIM). The probe's utility is demonstrated in visualizing neuronal Msrs activity and distribution within the mouse brain, which reveals a marked downregulation of Msrs activity in an AD model, highlighting the probe's potential in elucidating redox-related pathological mechanisms underlying neurodegenerative disorders.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40366085","pmcid":null,"openalex_id":null,"authors":[],"funders":[{"funder_name":"Science and Technology Commission of Shanghai Municipality","grant_id":"TQ20240206","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"22274055","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"22322405","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"22393930","title":null},{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"","title":null}],"total_grants":5,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":"https://doi.org/10.15223/policy-029","oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/jacs.5c03235","host_type":"publisher"}],"fields_of_study":["Mitochondria","Animals","Methionine Sulfoxide Reductases","Mice","Luminescent Measurements","Oxidation-Reduction","Brain","Humans","Alzheimer Disease","Fluorescent Dyes","Optical Imaging"],"mesh_terms":["Brain","Mitochondria","Animals","Humans","Mice","Alzheimer Disease","Fluorescent Dyes","Luminescent Measurements","Oxidation-Reduction","Methionine Sulfoxide Reductases","Optical Imaging"],"keywords":[],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T16:53:02.309483Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}