{"doi":"10.1021/jacs.5c01753","title":"Dynamic Kinetic Asymmetric Hydroacylation: Racemization by Soft Enolization","abstract":"We report a dynamic kinetic asymmetric transformation (DyKAT) of racemic aldehydes by Rh-catalyzed hydroacylation of acrylamides. This intermolecular hydroacylation generates 1,4-ketoamides with high enantio- and diastereoselectivity. DFT and experimental studies provide mechanistic insights and reveal an unexpected Rh-catalyzed pathway for aldehyde racemization. Our study represents a pioneering kinetic resolution by intermolecular hydroacylation and contributes to the growing field of stereoconvergent catalysis featuring C-C bond construction.","journal":"Journal of the American Chemical Society","year":2025,"id":521079,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9526,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":890217,"name":"Stephanie A. Corio","orcid":"0000-0001-9029-3895","position":1,"is_corresponding":false},{"id":1011957,"name":"Josephine M. Warnica","orcid":null,"position":2,"is_corresponding":false},{"id":1391371,"name":"Erin L. Kuker","orcid":null,"position":3,"is_corresponding":false},{"id":1054162,"name":"Alexander Lu","orcid":"0000-0001-7531-9073","position":4,"is_corresponding":false},{"id":651913,"name":"Jennifer S. Hirschi","orcid":"0000-0002-3470-0561","position":5,"is_corresponding":false},{"id":589747,"name":"Vy M. Dong","orcid":"0000-0002-8099-1048","position":6,"is_corresponding":false},{"id":1037285,"name":"Mengfei Xu","orcid":"0000-0002-9486-9887","position":0,"is_corresponding":true}],"reference_count":118,"raw_metadata":null,"created_at":"2026-07-19T02:49:32.958846Z","pmid":"40298317","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}