{"doi":"10.1021/jacs.4c14536","title":"Metallo-azapeptides: Controlled Metal Chelation to Peptide Backbone Nitrogen","abstract":"We present the first approach to controlled metal chelation of peptide backbones, where the anchoring site is an aza-amino acid nitrogen and the directionality of chelation events is dictated by the acidity of neighboring NHs. Selective backbone chelation precludes the need for metal-binding side chains and/or free N - or C -termini in peptides. We show that the presence and location of an aza-amino acid impact complex formation and report the first X-ray crystal structures of azapeptides bound to palladium and nickel. Evidence of atropisomerism in metallo-azapeptides is also presented.","journal":"Journal of the American Chemical Society","year":2025,"id":529832,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9501,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1409200,"name":"Evan L. Willis","orcid":"0000-0003-4494-6183","position":1,"is_corresponding":false},{"id":1409642,"name":"Meric D. Trombley","orcid":null,"position":2,"is_corresponding":false},{"id":588282,"name":"Chun‐Hsing Chen","orcid":"0000-0003-0150-9557","position":3,"is_corresponding":false},{"id":1152994,"name":"Caroline Proulx","orcid":"0000-0003-3851-793X","position":4,"is_corresponding":false},{"id":1409199,"name":"Maxwell O. Bowles","orcid":"0000-0001-9079-8260","position":0,"is_corresponding":true}],"reference_count":66,"raw_metadata":null,"created_at":"2026-07-19T02:51:01.235017Z","pmid":"39761202","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}