{"doi":"10.1021/jacs.4c13872","title":"Visible Light Triggerable CO Releasing Micelles","abstract":"Carbon monoxide (CO), along with nitric oxide and hydrogen sulfide, is one of a trinity of known gasotransmitters, or endogenously produced gaseous molecules that signal and regulate a panoply of physiological functions. CO releasing molecules (CORMs) are chemical tools that enable the study and application of this ephemeral gas, that, ideally, release CO on-demand when externally stimulated. Surveying the available triggers, photolysis is potentially advantageous: It is contactless and grants practitioners unparalleled spatial and temporal control. However, current phototriggered CORMs are capricious and do not meet current needs. Presented here is a highly efficient platform for the visible light triggered release of CO gas. This platform is built on a unique CO containing functionality, the cyclopropenone, which undergoes facile decarbonylation through visible light (470 nm) mediated photoredox catalysis. Due to the exothermic strain-release that occurs upon formation of CO, this photoreaction is rapid, quantitative, and has tunable release rates. To render this photo-CORM water-soluble, deliverable, and to keep reactants in proximity, necessary components were polymerized into block copolymers that self-assemble into CO releasing micelles (CORMIs). This platform was compared directly to other state-of-the-art CORMs, showing significantly improved CO production efficiency, lower toxicity, tunable release rates, and consistent efficacy in ex vivo and in vitro settings.","journal":"Journal of the American Chemical Society","year":2024,"id":425813,"datarank":0.4566783656585135,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.0,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9565,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1224617,"name":"Ram Ambre","orcid":null,"position":1,"is_corresponding":false},{"id":1224088,"name":"Riya Joshi","orcid":"0000-0002-3433-8136","position":2,"is_corresponding":false},{"id":1224618,"name":"Jeffrey D. Amidon","orcid":null,"position":3,"is_corresponding":false},{"id":1224619,"name":"J.L. Snow","orcid":null,"position":4,"is_corresponding":false},{"id":1224620,"name":"Vivian C. Lawless","orcid":null,"position":5,"is_corresponding":false},{"id":246038,"name":"Brady T. Worrell","orcid":"0000-0001-7472-2063","position":6,"is_corresponding":false},{"id":1137688,"name":"Mckenna G. Hanson","orcid":"0000-0003-4342-9299","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:58:32.160975Z","pmid":"39663914","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}