{"doi":"10.1021/jacs.4c13596","title":"Enantioselective [2π + 2σ] Photocycloaddition Enabled by Brønsted Acid Catalyzed Chromophore Activation","abstract":"Bicyclo[2.1.1]hexanes have emerged as valuable scaffolds for the design of new pharmaceutical and agrochemical active ingredients. These structures can be efficiently synthesized via [2π + 2σ] photocycloadditions; however, control over the absolute stereochemistry of these strain-releasing reactions has remained challenging. Herein, we demonstrate that Brønsted acid catalyzed chromophore activation of C -acyl imidazoles enables highly enantioselective [2π + 2σ] photocycloadditions. Because this approach is agnostic to the identity of the coupling partner, the same strategy can be used to synthesize several other medicinally relevant strained small-ring structures.","journal":"Journal of the American Chemical Society","year":2024,"id":418291,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":53,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9457,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1205788,"name":"Ruoyu Zoe Qian","orcid":"0000-0002-5561-5067","position":1,"is_corresponding":false},{"id":1205789,"name":"Rodrigo Villanueva","orcid":"0009-0009-9862-9408","position":2,"is_corresponding":false},{"id":1205790,"name":"Darren L. Poole","orcid":"0000-0001-5050-5996","position":3,"is_corresponding":false},{"id":1206623,"name":"Tay Rosenthal","orcid":null,"position":4,"is_corresponding":false},{"id":300706,"name":"Tehshik P. Yoon","orcid":"0000-0002-3934-4973","position":5,"is_corresponding":false},{"id":1080391,"name":"Ellie F. Plachinski","orcid":null,"position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":null,"created_at":"2026-07-19T01:57:02.483590Z","pmid":"39508316","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}