{"doi":"10.1021/jacs.4c13101","title":"Concise Biosynthesis of Antifungal Papulacandins","abstract":"We report the complete biosynthesis of antifungal papulacandins through heterologous expression and enzymatic assays. The papulacandin biosynthesis follows a convergent five-component strategy, involving a linear polyketide chain that is synthesized and installed to the aryl-glucoside by a polyketide synthase fused with a C-terminal acyltransferase domain. The formation of the challenging tricyclic benzannulated spiroketal core is initiated by the C -glycosylation of 5-(hydroxymethyl)resorcinol, followed by spirocyclization catalyzed by a Fe(II)/α-ketoglutarate-dependent oxygenase PpcE.","journal":"Journal of the American Chemical Society","year":2025,"id":531174,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9452,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1411925,"name":"Niandi Zhang","orcid":null,"position":1,"is_corresponding":false},{"id":1411452,"name":"Jinmei Li","orcid":"0000-0001-5205-4631","position":2,"is_corresponding":false},{"id":1411453,"name":"Mingxin Zheng","orcid":"0000-0001-8461-8980","position":3,"is_corresponding":false},{"id":1247836,"name":"Meihui Zhao","orcid":null,"position":4,"is_corresponding":false},{"id":392387,"name":"Lingyan Wang","orcid":"0000-0001-9236-7229","position":5,"is_corresponding":false},{"id":105313,"name":"Zhiqiang An","orcid":"0000-0001-9309-2335","position":6,"is_corresponding":false},{"id":388622,"name":"Gerald F. Bills","orcid":"0000-0003-2352-8417","position":7,"is_corresponding":false},{"id":1029204,"name":"Zhuan Zhang","orcid":"0000-0002-3300-3035","position":8,"is_corresponding":false},{"id":644189,"name":"Chao Yu","orcid":"0000-0002-6929-6693","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-19T02:51:14.579161Z","pmid":"40042210","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}