{"doi":"10.1021/jacs.4c05978","title":"Lutetium Texaphyrin–Celecoxib Conjugate as a Potential Immuno-Photodynamic Therapy Agent","abstract":"Immuno-photodynamic therapy (IPDT) has emerged as a new modality for cancer treatment. Novel photosensitizers can help achieve the promise inherent in IPDT, namely, the complete eradication of a tumor without recurrence. We report here a small molecule photosensitizer conjugate, LuCXB. This IPDT agent integrates a celecoxib (cyclooxygenase-2 inhibitor) moiety with a near-infrared absorbing lutetium texaphyrin photocatalytic core. In aqueous environments, the two components of LuCXB are self-associated through inferred donor–acceptor interactions. A consequence of this intramolecular association is that upon photoirradiation with 730 nm light, LuCXB produces superoxide radicals (O 2 –• ) via a type I photodynamic pathway; this provides a first line of defense against the tumor while promoting IPDT. For in vivo therapeutic applications, we prepared a CD133-targeting, aptamer-functionalized exosome-based nanophotosensitizer (Ex-apt@LuCXB) designed to target cancer stem cells. Ex-apt@LuCXB was found to display good photosensitivity, acceptable biocompatibility, and robust tumor targetability. Under conditions of photoirradiation, Ex-apt@LuCXB acts to amplify IPDT while exerting a significant antitumor effect in both liver and breast cancer mouse models. The observed therapeutic effects are attributed to a synergistic mechanism that combines antiangiogenesis and photoinduced cancer immunotherapy.","journal":"Journal of the American Chemical Society","year":2024,"id":418354,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":52,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9531,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1205869,"name":"Kongpeng Lv","orcid":"0000-0001-6270-639X","position":1,"is_corresponding":false},{"id":655304,"name":"Calvin V. Chau","orcid":"0000-0003-2479-8590","position":2,"is_corresponding":false},{"id":1206716,"name":"Jong Hyeon Lim","orcid":null,"position":3,"is_corresponding":false},{"id":1205870,"name":"Rakesh Parida","orcid":"0000-0003-1209-6866","position":4,"is_corresponding":false},{"id":1205871,"name":"Xin Huang","orcid":"0000-0002-0413-3340","position":5,"is_corresponding":false},{"id":1205872,"name":"Snehasish Debnath","orcid":"0000-0001-8342-7496","position":6,"is_corresponding":false},{"id":638379,"name":"Yunjie Xu","orcid":"0000-0003-0730-8473","position":7,"is_corresponding":false},{"id":1205873,"name":"Siqi Zheng","orcid":"0000-0003-0917-6646","position":8,"is_corresponding":false},{"id":107368,"name":"Adam C. Sedgwick","orcid":"0000-0002-3132-2913","position":9,"is_corresponding":false},{"id":1205874,"name":"Jin Yong Lee","orcid":"0000-0003-0360-5059","position":10,"is_corresponding":false},{"id":1205875,"name":"Dixian Luo","orcid":"0000-0001-6155-8137","position":11,"is_corresponding":false},{"id":409382,"name":"Quan Liu","orcid":"0000-0001-9994-3743","position":12,"is_corresponding":false},{"id":107373,"name":"Jonathan L. Sessler","orcid":"0000-0002-9576-1325","position":13,"is_corresponding":false},{"id":638388,"name":"Jong Seung Kim","orcid":"0000-0003-3477-1172","position":14,"is_corresponding":false},{"id":638381,"name":"Jusung An","orcid":"0000-0003-4324-2782","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-19T01:57:02.483590Z","pmid":"38959476","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}