{"doi":"10.1021/jacs.3c12436","title":"Generality-Driven Catalyst Development: A Universal Catalyst for Enantioselective Nitroalkene Reduction","abstract":"Cracking the selectivity-generality paradox is among the most pressing challenges in asymmetric catalysis. This obstacle prevents the immediate and successful translation of new methods to diverse small molecules. This is particularly rate-limiting for therapeutic development, where availability and structural diversity are often critical components of successful campaigns. Here we describe the union of generality-driven enantioselective catalysis and the preparation of diverse peptidomimetics. A single new organocatalyst provides high selectivity and substrate generality that is matched only by a combination of metal and organocatalysts. Within organocatalysis, this discovery breaks a 16-year monolithic paradigm, uncovering a powerful new scaffold for enantioselective reduction with behavior that suggests the recognition of a nitroethylene minimal catalaphile.","journal":"Journal of the American Chemical Society","year":2024,"id":430070,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9477,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":697098,"name":"Melanie A. Padalino","orcid":"0000-0001-8936-5468","position":1,"is_corresponding":false},{"id":1233575,"name":"Julius E. L. Jan","orcid":null,"position":2,"is_corresponding":false},{"id":1233075,"name":"Sang-Jun Park","orcid":"0009-0000-0899-9670","position":3,"is_corresponding":false},{"id":1233576,"name":"Michael W. Danneman","orcid":null,"position":4,"is_corresponding":false},{"id":859054,"name":"Jeffrey N. Johnston","orcid":"0000-0002-0885-636X","position":5,"is_corresponding":false},{"id":931788,"name":"Zihang Deng","orcid":"0000-0002-5377-7484","position":0,"is_corresponding":true}],"reference_count":63,"raw_metadata":null,"created_at":"2026-07-19T01:59:16.092672Z","pmid":"38176098","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}