{"doi":"10.1021/jacs.3c09883","title":"Stimulus-Induced Relief of Intentionally Incorporated Frustration Drives Refolding of a Water-Soluble Biomimetic Foldamer","abstract":"Frustrated, or nonoptimal, interactions have been proposed to be essential to a protein's ability to display responsive behavior such as allostery, conformational signaling, and signal transduction. However, the intentional incorporation of frustrated noncovalent interactions has not been explored as a design element in the field of dynamic foldamers. Here, we report the design, synthesis, characterization, and molecular dynamics simulations of the first dynamic water-soluble foldamer that, in response to a stimulus, exploits relief of frustration in its noncovalent network to structurally rearrange from a pleated to an intercalated columnar structure. Thus, relief of frustration provides the energetic driving force for structural rearrangement. This work represents a previously unexplored design element for the development of stimulus-responsive systems that has potential application to materials chemistry, synthetic biology, and molecular machines.","journal":"Journal of the American Chemical Society","year":2023,"id":355384,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9493,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1103351,"name":"Adam J. Sowers","orcid":"0009-0001-9324-595X","position":1,"is_corresponding":false},{"id":936196,"name":"Christopher R. Travis","orcid":"0000-0003-0673-6978","position":2,"is_corresponding":false},{"id":1103352,"name":"Troy D. Vulpis","orcid":"0000-0002-6407-7133","position":3,"is_corresponding":false},{"id":1103353,"name":"Thomas A. Cope","orcid":"0009-0000-4579-5861","position":4,"is_corresponding":false},{"id":1103354,"name":"Sarah K. Ouslander","orcid":"0009-0003-3579-7152","position":5,"is_corresponding":false},{"id":1103355,"name":"Alexander F. Russell","orcid":"0009-0006-2995-9276","position":6,"is_corresponding":false},{"id":547061,"name":"Michel R. Gagné","orcid":"0000-0001-8424-5547","position":7,"is_corresponding":false},{"id":1103356,"name":"Vojislava Pophristic","orcid":"0000-0002-8848-2651","position":8,"is_corresponding":false},{"id":1103357,"name":"Zhiwei Liu","orcid":"0000-0003-1020-7948","position":9,"is_corresponding":false},{"id":374771,"name":"Marcey L. Waters","orcid":"0000-0002-4917-5755","position":10,"is_corresponding":false},{"id":1103350,"name":"Hanne C. Henriksen","orcid":"0009-0006-4238-3670","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-19T01:13:16.394812Z","pmid":"38054648","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}