{"doi":"10.1021/jacs.3c08769","title":"Cobalt-Catalyzed Asymmetric Reductive Alkenylation and Arylation of Heterobiaryl Tosylates: Kinetic Resolution or Dynamic Kinetic Resolution?","abstract":null,"journal":"Journal of the American Chemical Society","year":2023,"id":649856,"datarank":0.5676284450877392,"base_score":3.784189633918261,"endowment":3.784189633918261,"self_citation_contribution":0.5676284450877392,"citation_network_contribution":0.0,"self_endowment_contribution":0.5676284450877392,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":709187,"name":"Chuan Wang","orcid":"0000-0001-5165-8273","position":1,"is_corresponding":false},{"id":501616,"name":"Haiyan Dong","orcid":"0000-0001-9468-0841","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Cobalt-Catalyzed Asymmetric Reductive Alkenylation and Arylation of Heterobiaryl Tosylates: Kinetic Resolution or Dynamic Kinetic Resolution?","abstract":"Herein, we report a cobalt-catalyzed atroposelective reductive cross-coupling of racemic heterobiaryl tosylates with a C(sp 2 )–X type electrophile. Both aryl and alkenyl halides are competent precursors for this reaction, providing a variety of heterobiaryls as the products in a highly enantioselective manner with high functionality tolerance. The related asymmetric arylation and alkenylation are discovered to proceed with divergent mechanisms. The reaction pathway changes from kinetic resolution (KR) when alkenyl bromides and aryl iodides bearing strong electron-withdrawing substitution on the para -position are employed as the starting materials to an enantioconvergent transformation via dynamic KR of configurationally labile cobaltacycles when relatively electron-rich aryl iodides are used. The change of the reaction mechanisms turns out to arise from the relative rates of two competing elementary steps, which are the epimerization of the cyclic Co(I) intermediates and their trapping by the coupling electrophiles of the C(sp 2 )-type via oxidative addition.","is_dataset_classified":null,"base_score":3.7612001156935624,"endowment":3.7612001156935624,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"38018138","pmcid":null,"openalex_id":"https://openalex.org/W4389144220","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"22071230","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"22271267","title":null}],"total_grants":2,"fwci":4.8129,"citation_percentile":0.96452774,"influential_citations":0,"citation_trend":[{"year":2024,"count":18},{"year":2025,"count":14},{"year":2026,"count":10}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-029","oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/jacs.3c08769","host_type":"publisher"},{"url":"https://doi.org/10.1021/jacs.3c08769","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/38018138","host_type":"repository"}],"fields_of_study":["Catalytic C–H Functionalization Methods","Axial and Atropisomeric Chirality Synthesis","Asymmetric Synthesis and Catalysis"],"mesh_terms":[],"keywords":["Chemistry","Kinetic resolution","Kinetic energy","Cobalt","Catalysis","Resolution (logic)","Combinatorial chemistry","Photochemistry","Inorganic chemistry","Organic chemistry","Enantioselective synthesis"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T04:25:49.312283Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}