{"doi":"10.1021/jacs.3c08012","title":"A Bioorthogonal Decaging Chemistry of <i>N</i>-Oxide and Silylborane for Prodrug Activation both <i>In Vitro</i> and <i>In Vivo</i>","abstract":null,"journal":"Journal of the American Chemical Society","year":2023,"id":662137,"datarank":0.5101796072493234,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"self_citation_contribution":0.5101796072493234,"citation_network_contribution":0.0,"self_endowment_contribution":0.5101796072493234,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1728561,"name":"Yiyao Pan","orcid":null,"position":1,"is_corresponding":false},{"id":1728562,"name":"Guofeng Jiao","orcid":null,"position":2,"is_corresponding":false},{"id":1728563,"name":"Mengyu Xu","orcid":null,"position":3,"is_corresponding":false},{"id":1728564,"name":"Dongguang Fan","orcid":null,"position":4,"is_corresponding":false},{"id":138515,"name":"Ziwei Hu","orcid":null,"position":5,"is_corresponding":false},{"id":785035,"name":"Jiarui Wu","orcid":"0000-0002-1617-6110","position":6,"is_corresponding":false},{"id":655692,"name":"Tao Chen","orcid":"0000-0002-6552-3457","position":7,"is_corresponding":false},{"id":703217,"name":"Miao Liu","orcid":"0000-0003-4248-2661","position":8,"is_corresponding":false},{"id":1649076,"name":"Xiaoguang Bao","orcid":null,"position":9,"is_corresponding":false},{"id":1728565,"name":"Hengte Ke","orcid":"0000-0002-3413-3376","position":10,"is_corresponding":false},{"id":683036,"name":"Xingyue Ji","orcid":"0000-0002-2728-8740","position":11,"is_corresponding":false},{"id":1728560,"name":"Zhicheng Yan","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A Bioorthogonal Decaging Chemistry of <i>N</i>-Oxide and Silylborane for Prodrug Activation both <i>In Vitro</i> and <i>In Vivo</i>","abstract":"Bioorthogonal decaging chemistry with both fast kinetics and high efficiency is highly demanded for in vivo applications but remains very sporadic. Herein, we describe a new bioorthogonal decaging chemistry between N -oxide and silylborane. A simple replacement of “C” in boronic acid with “Si” was able to substantially accelerate the N -oxide decaging kinetics by 10 6 fold ( k 2: up to 10 3 M –1 s –1 ). Moreover, a new N -oxide-masked self-immolative spacer was developed for the traceless release of various payloads upon clicking with silylborane with fast kinetics and high efficiency (>90%). Impressively, one such N -oxide-based self-assembled bioorthogonal nano-prodrug in combination with silylborane led to significantly enhanced tumor suppression effects as compared to the parent drug in a 4T1 mouse breast tumor model. In aggregate, this new bioorthogonal click-and-release chemistry is featured with fast kinetics and high efficiency and is perceived to find widespread applications in chemical biology and drug delivery.","is_dataset_classified":null,"base_score":3.4011973816621555,"endowment":3.4011973816621555,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37933858","pmcid":null,"openalex_id":"https://openalex.org/W4388454456","authors":[],"funders":[{"funder_name":"Jiangsu Provincial Key Research and Development Program","grant_id":"BE2020763","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"22277087","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"32071373","title":null},{"funder_name":"Jiangsu Province Engineering Research Center of Precision Diagnostics and Therapeutics Development","grant_id":"","title":null},{"funder_name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","grant_id":"","title":null}],"total_grants":5,"fwci":3.3223,"citation_percentile":0.93545681,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":9},{"year":2025,"count":12},{"year":2026,"count":7}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-029","oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/jacs.3c08012","host_type":"publisher"},{"url":"https://doi.org/10.1021/jacs.3c08012","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37933858","host_type":"repository"}],"fields_of_study":["Click Chemistry and Applications","Chemical Synthesis and Analysis","Peptidase Inhibition and Analysis","Prodrugs","Animals","Mice","Boranes","Cell Line, Tumor","Female","Humans","Antineoplastic Agents","Molecular Structure","Click Chemistry","Mice, Inbred BALB C"],"mesh_terms":["Animals","Antineoplastic Agents","Boranes","Female","Humans","Mice, Inbred BALB C","Prodrugs","Molecular Structure","Cell Line, Tumor","Mice","Click Chemistry"],"keywords":["Chemistry","Bioorthogonal chemistry","Prodrug","In vivo","In vitro","Combinatorial chemistry","Biochemistry","Click chemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T12:51:51.079332Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}