{"doi":"10.1021/jacs.3c07849","title":"Synthesis of (−)-Cotylenol, a 14-3-3 Molecular Glue Component","abstract":"Small molecules that modulate the 14-3-3 protein-protein interaction (PPI) network represent valuable therapeutics and tool compounds. However, access has been lost to 14-3-3 PPI molecular glues of the cotylenin class, leading to investigations into the practical chemical syntheses of congeners and analogues. Here we report a concise synthesis of (-)-cotylenol via a 10-step asymmetric entry into a diversifiable 5-8-5 core. This route features a mild Liebeskind-Srogl fragment coupling that tolerates unprecedented steric hindrance to produce a highly congested ketone, and a tandem Claisen-ene cascade that establishes the 8-membered ring. Late-stage control of stereochemistry and functionality leads to (-)-cotylenol and sets the stage for focused library synthesis.","journal":"Journal of the American Chemical Society","year":2023,"id":332450,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":25,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9575,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":572759,"name":"Dylan W. Snelson","orcid":"0000-0003-2782-6243","position":1,"is_corresponding":false},{"id":993430,"name":"Tucker R. Huffman","orcid":"0000-0002-6799-3057","position":2,"is_corresponding":false},{"id":993959,"name":"Akihiro Kuroo","orcid":null,"position":3,"is_corresponding":false},{"id":993431,"name":"Ryota Sato","orcid":"0009-0005-6940-9159","position":4,"is_corresponding":false},{"id":231109,"name":"Ryan A. Shenvi","orcid":"0000-0001-8353-6449","position":5,"is_corresponding":false},{"id":1058619,"name":"Stephen I. Ting","orcid":"0000-0002-6146-8112","position":0,"is_corresponding":true}],"reference_count":94,"raw_metadata":null,"created_at":"2026-07-19T01:09:30.139849Z","pmid":"37683289","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}