{"doi":"10.1021/jacs.3c07727","title":"Revisiting Coley’s Toxins: Immunogenic Cardiolipins from <i>Streptococcus pyogenes</i>","abstract":"High Resolution Image Download MS PowerPoint Slide Coley’s toxins, an early and enigmatic form of cancer (immuno)therapy, were based on preparations of Streptococcus pyogenes . As part of a program to explore bacterial metabolites with immunomodulatory potential, S . pyogenes metabolites were assayed in a cell-based immune assay, and a single membrane lipid, 18:1/18:0/18:1/18:0 cardiolipin, was identified. Its activity was profiled in additional cellular assays, which showed it to be an agonist of a TLR2–TLR1 signaling pathway with a 6 μM EC 50 and robust TNF-α induction. A synthetic analog with switched acyl chains had no measurable activity in immune assays. The identification of a single immunogenic cardiolipin with a restricted structure–activity profile has implications for immune regulation, cancer immunotherapy, and poststreptococcal autoimmune diseases.","journal":"Journal of the American Chemical Society","year":2023,"id":337635,"datarank":0.6392668432819244,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.19760099640695833,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.19760099640695833,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":15,"citers_with_citation_signal":12,"citers_with_endowment":12,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9591,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1029547,"name":"Sunghee Bang","orcid":"0000-0002-6764-7373","position":1,"is_corresponding":false},{"id":16996,"name":"Sung‐Moo Park","orcid":"0000-0002-7505-1617","position":2,"is_corresponding":false},{"id":542393,"name":"Xiao Ma","orcid":"0000-0002-9842-9045","position":3,"is_corresponding":false},{"id":234829,"name":"Chelsi D. Cassilly","orcid":"0000-0001-9611-7438","position":4,"is_corresponding":false},{"id":6340,"name":"Daniel B. Graham","orcid":"0000-0002-8403-8115","position":5,"is_corresponding":false},{"id":104389,"name":"Ramnik J. Xavier","orcid":"0000-0002-5630-5167","position":6,"is_corresponding":false},{"id":79205,"name":"Jon Clardy","orcid":"0000-0003-0213-8356","position":7,"is_corresponding":false},{"id":79207,"name":"Yern‐Hyerk Shin","orcid":null,"position":0,"is_corresponding":true}],"reference_count":35,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:10:31.133446Z","pmid":"37738205","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}