{"doi":"10.1021/jacs.3c04850","title":"Enantiocontrolled Total Synthesis of (−)-Retigeranic Acid A","abstract":null,"journal":"Journal of the American Chemical Society","year":2023,"id":591076,"datarank":1.1604446969614797,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"self_citation_contribution":0.5456379239589579,"citation_network_contribution":0.6148067730025216,"self_endowment_contribution":0.5456379239589579,"citer_contribution":0.6148067730025216,"corpus_percentile":null,"corpus_rank":null,"citation_count":37,"citer_count":36,"citers_with_citation_signal":27,"citers_with_endowment":27,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1512233,"name":"Weidong Yao","orcid":null,"position":1,"is_corresponding":false},{"id":1512234,"name":"Hufeng Zheng","orcid":null,"position":2,"is_corresponding":false},{"id":199540,"name":"Hongyu Wang","orcid":null,"position":3,"is_corresponding":false},{"id":1011675,"name":"Panpan Zhou","orcid":"0000-0001-8111-8155","position":4,"is_corresponding":false},{"id":1512235,"name":"Dao-Yong Zhu","orcid":null,"position":5,"is_corresponding":false},{"id":1512236,"name":"Shao-Hua Wang","orcid":"0000-0002-4347-8245","position":6,"is_corresponding":false},{"id":385809,"name":"Xiaoming Chen","orcid":"0009-0001-3231-2565","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Enantiocontrolled Total Synthesis of (−)-Retigeranic Acid A","abstract":"The asymmetric total synthesis of (−)-retigeranic acid A has been realized. The key features of the current synthesis include (1) a Pt-catalyzed Conia-ene 5- exo-dig cyclization of enolyne to establish the key quaternary stereochemical center of C-10 (D/E ring), (2) an intramolecular diastereoselective Prins cyclization to construct the trans -hydrindane backbone (A/B ring), and (3) a late-stage intramolecular Fe-mediated hydrogen atom transfer (HAT) Baldwin-disfavored 5- endo - trig radical cyclization to rapidly assemble vicinal quaternary centers and the core structure of (−)-retigeranic acid A (C ring).","is_dataset_classified":null,"base_score":3.6375861597263857,"endowment":3.6375861597263857,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37307044","pmcid":null,"openalex_id":"https://openalex.org/W4380291310","authors":[],"funders":[{"funder_name":"Science and Technology Program of Gansu Province","grant_id":"22JR5RA479","title":null},{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"lzujbky-2020-41","title":null},{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"lzujbky-2020-ct01","title":null},{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"lzujbky-2022-ct03","title":null},{"funder_name":"Fundamental Research Funds for the Central Universities","grant_id":"lzujbky-2022-sp09","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"22231003","title":null},{"funder_name":"Gansu Province","grant_id":"2022GSMPA0010","title":null},{"funder_name":"Collaborative Innovation Center for Northwestern Chinese Medicine of Lanzhou University","grant_id":"","title":null}],"total_grants":8,"fwci":8.2971,"citation_percentile":0.9835113,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":11},{"year":2025,"count":19},{"year":2026,"count":6}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-029","oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/jacs.3c04850","host_type":"publisher"},{"url":"https://doi.org/10.1021/jacs.3c04850","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37307044","host_type":"repository"}],"fields_of_study":["Phytochemistry and Bioactivity Studies","Marine Sponges and Natural Products","Alkaloids: synthesis and pharmacology"],"mesh_terms":[],"keywords":["Chemistry","Intramolecular force","Ring (chemistry)","Stereochemistry","Total synthesis","Vicinal","Radical cyclization","Prins reaction","Hydrogen atom","Intramolecular reaction","Catalysis","Organic chemistry","Group (periodic table)"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-25T14:11:11.161918Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}