{"doi":"10.1021/jacs.3c02735","title":"Optical Control of Dopamine D2-like Receptors with Cell-Specific Fast-Relaxing Photoswitches","abstract":"Dopamine D2-like receptors (D2R, D3R, and D4R) control diverse physiological and behavioral functions and are important targets for the treatment of a variety of neuropsychiatric disorders. Their complex distribution and activation kinetics in the brain make it difficult to target specific receptor populations with sufficient precision. We describe a new toolkit of light-activatable, fast-relaxing, covalently taggable chemical photoswitches that fully activate, partially activate, or block D2-like receptors. This technology combines the spatiotemporal precision of a photoswitchable ligand (P) with cell type and spatial specificity of a genetically encoded membrane anchoring protein (M) to which the P tethers. These tools set the stage for targeting endogenous D2-like receptor signaling with molecular, cellular, and spatiotemporal precision using only one wavelength of light.","journal":"Journal of the American Chemical Society","year":2023,"id":340087,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9531,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":665066,"name":"Prashant Donthamsetti","orcid":"0009-0006-6979-1180","position":1,"is_corresponding":false},{"id":737220,"name":"Zisis Peitsinis","orcid":"0000-0003-0736-8011","position":2,"is_corresponding":false},{"id":665672,"name":"Cherise Stanley","orcid":null,"position":3,"is_corresponding":false},{"id":166216,"name":"Dirk Trauner","orcid":"0000-0002-6782-6056","position":4,"is_corresponding":false},{"id":292946,"name":"Ehud Y. Isacoff","orcid":"0000-0003-4775-9359","position":5,"is_corresponding":false},{"id":815626,"name":"Belinda E. Hetzler","orcid":"0000-0002-0372-9126","position":0,"is_corresponding":true}],"reference_count":84,"raw_metadata":null,"created_at":"2026-07-19T01:10:54.145367Z","pmid":"37586061","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}