{"doi":"10.1021/jacs.3c02273","title":"Fenton-like Chemistry by a Copper(I) Complex and H<sub>2</sub>O<sub>2</sub> Relevant to Enzyme Peroxygenase C–H Hydroxylation","abstract":"Lytic polysaccharide monooxygenases have received significant attention as catalytic convertors of biomass to biofuel. Recent studies suggest that its peroxygenase activity (i.e., using H 2 O 2 as an oxidant) is more important than its monooxygenase functionality. Here, we describe new insights into peroxygenase activity, with a copper(I) complex reacting with H 2 O 2 leading to site-specific ligand–substrate C–H hydroxylation. [Cu I (TMG 3 tren)] + ( 1 ) (TMG 3 tren = 1,1,1-Tris{2-[ N 2 -(1,1,3,3-tetramethylguanidino)]ethyl}amine) and a dry source of hydrogen peroxide, ( o -Tol 3 P═O·H 2 O 2 ) 2 react in the stoichiometry, [Cu I (TMG 3 tren)] + + H 2 O 2 → [Cu I (TMG 3 tren-OH)] + + H 2 O, wherein a ligand N -methyl group undergoes hydroxylation giving TMG 3 tren-OH. Furthermore, Fenton-type chemistry (Cu I + H 2 O 2 → Cu II -OH + ·OH) is displayed, in which (i) a Cu(II)-OH complex could be detected during the reaction and it could be separately isolated and characterized crystallographically and (ii) hydroxyl radical (·OH) scavengers either quenched the ligand hydroxylation reaction and/or (iii) captured the ·OH produced.","journal":"Journal of the American Chemical Society","year":2023,"id":318906,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":60,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9521,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1026986,"name":"Magdalene T. Brueggemeyer","orcid":"0000-0002-0205-8033","position":1,"is_corresponding":false},{"id":271047,"name":"Wesley J. Transue","orcid":"0000-0001-7445-5663","position":2,"is_corresponding":false},{"id":1026987,"name":"Younwoo Park","orcid":"0000-0003-3749-8108","position":3,"is_corresponding":false},{"id":1026988,"name":"Jaeheung Cho","orcid":"0000-0002-2712-4295","position":4,"is_corresponding":false},{"id":414296,"name":"Maxime A. Siegler","orcid":"0000-0003-4165-7810","position":5,"is_corresponding":false},{"id":271050,"name":"Edward I. Solomon","orcid":"0000-0003-0291-3199","position":6,"is_corresponding":false},{"id":414300,"name":"Kenneth D. Karlin","orcid":"0000-0002-5675-7040","position":7,"is_corresponding":false},{"id":981287,"name":"Bohee Kim","orcid":"0000-0002-0554-3392","position":0,"is_corresponding":true}],"reference_count":91,"raw_metadata":null,"created_at":"2026-07-19T01:07:06.454099Z","pmid":"37195014","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}