{"doi":"10.1021/jacs.2c13584","title":"Total Synthesis of (+)-Shearilicine","abstract":"Herein we report the first total synthesis of the indole diterpenoid natural product shearilicine by an 11-step sequence via a generalizable precursor to the highly oxidized subclass of indole diterpenoids. A native chiral auxiliary strategy was employed to access the target molecule in an enantiospecific fashion. The formation of the key carbazole substructure was achieved through a mild intramolecular Heck cyclization, wherein a computational study revealed noncovalent substrate-ligand and ligand-ligand interactions that promoted migratory insertion.","journal":"Journal of the American Chemical Society","year":2023,"id":334323,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9385,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1012842,"name":"Yingchuan Zhu","orcid":null,"position":1,"is_corresponding":false},{"id":1012514,"name":"Shingo Harada","orcid":"0000-0002-8373-4143","position":2,"is_corresponding":false},{"id":1012843,"name":"Isaiah Aguilar","orcid":null,"position":3,"is_corresponding":false},{"id":559097,"name":"Abbigayle E. Cuomo","orcid":"0000-0003-2117-0925","position":4,"is_corresponding":false},{"id":1012515,"name":"Minghao Wang","orcid":"0009-0001-2171-3873","position":5,"is_corresponding":false},{"id":374732,"name":"Timothy R. Newhouse","orcid":"0000-0001-8741-7236","position":6,"is_corresponding":false},{"id":1062719,"name":"Daria E. Kim","orcid":"0000-0001-5711-7929","position":0,"is_corresponding":true}],"reference_count":65,"raw_metadata":null,"created_at":"2026-07-19T01:09:48.843291Z","pmid":"36790949","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}