{"doi":"10.1021/jacs.2c13512","title":"Structural Basis of Sirtuin 6-Catalyzed Nucleosome Deacetylation","abstract":null,"journal":"Journal of the American Chemical Society","year":2023,"id":598222,"datarank":0.6166310796259968,"base_score":4.110873864173311,"endowment":4.110873864173311,"self_citation_contribution":0.6166310796259968,"citation_network_contribution":0.0,"self_endowment_contribution":0.6166310796259968,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":60,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":58319,"name":"Jonathan W. 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The structure of Sirt6 bound to a nucleosome reveals extensive interactions between distinct segments of Sirt6 and the H2A/H2B acidic patch and nucleosomal DNA, which accounts for the rapid deacetylation of nucleosomal H3 sites and the disfavoring of histone H2B acetylation sites. These findings provide a new framework for understanding how HDACs target and regulate chromatin.","is_dataset_classified":null,"base_score":4.110873864173311,"endowment":4.110873864173311,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36930461","pmcid":"PMC10071992","openalex_id":"https://openalex.org/W4327685822","authors":[],"funders":[{"funder_name":"Division of Chemistry","grant_id":"2127882","title":null},{"funder_name":"American Heart Association","grant_id":"826614","title":null},{"funder_name":"Harvard Medical School","grant_id":"HMS 1929","title":null},{"funder_name":"American Cancer Society","grant_id":"PF-20-105-01-DMC","title":null},{"funder_name":"National Institute of General Medical Sciences","grant_id":"GM62437","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R01 GM062437","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R37 GM062437","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"R35 GM149229","title":null},{"funder_name":"Dana-Farber/Harvard Cancer Center","grant_id":"","title":null},{"funder_name":"Damon Runyon Cancer Research Foundation","grant_id":"","title":null},{"funder_name":"Health Resources in Action","grant_id":"","title":null}],"total_grants":11,"fwci":8.6625,"citation_percentile":0.98612213,"influential_citations":0,"citation_trend":[{"year":2023,"count":14},{"year":2024,"count":18},{"year":2025,"count":19},{"year":2026,"count":9}],"oa_status":"green","license":"https://doi.org/10.15223/policy-029","oa_locations":[{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10071992/pdf/nihms-1887154.pdf","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10071992/pdf/nihms-1887154.pdf","host_type":"repository"},{"url":"https://pubs.acs.org/doi/pdf/10.1021/jacs.2c13512","host_type":"publisher"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10071992","host_type":"repository"},{"url":"https://doi.org/10.1021/jacs.2c13512","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36930461","host_type":"repository"}],"fields_of_study":["Sirtuins and Resveratrol in Medicine","PARP inhibition in cancer therapy","Histone Deacetylase Inhibitors Research","Nucleosomes","Histones","Chromatin","Sirtuins","Acetylation","Glycosyltransferases","Catalysis"],"mesh_terms":["Acetylation","Catalysis","Chromatin","Histones","Nucleosomes","Glycosyltransferases","Sirtuins"],"keywords":["Nucleosome","Chemistry","Sirtuin","Histone","Acetylation","Histone H3","Histone Acetyltransferases","Histone octamer","Chromatin","Histone code","Histone methylation","Bromodomain","Biochemistry","Cell biology","DNA","Biology","Gene","Gene expression","DNA methylation"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"alphafold"},{"name":"pdb"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T15:18:19.977368Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}