{"doi":"10.1021/jacs.2c07220","title":"Red-Shifted Coumarin Luciferins for Improved Bioluminescence Imaging","abstract":"Multicomponent bioluminescence imaging in vivo requires an expanded collection of tissue-penetrant probes. Toward this end, we generated a new class of near-infrared (NIR) emitting coumarin luciferin analogues (CouLuc-3s). The scaffolds were easily accessed from commercially available dyes. Complementary mutant luciferases for the CouLuc-3 analogues were also identified. The brightest probes enabled sensitive imaging in vivo . The CouLuc-3 scaffolds are also orthogonal to popular bioluminescent reporters and can be used for multicomponent imaging applications. Collectively, this work showcases a new set of bioluminescent tools that can be readily implemented for multiplexed imaging in a variety of biological settings.","journal":"Journal of the American Chemical Society","year":2023,"id":321328,"datarank":0.5709993734655481,"base_score":3.8066624897703196,"endowment":3.8066624897703196,"self_citation_contribution":0.5709993734655481,"citation_network_contribution":0.0,"self_endowment_contribution":0.5709993734655481,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":44,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9444,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":671197,"name":"Donald R. Caldwell","orcid":"0000-0002-6023-3733","position":1,"is_corresponding":false},{"id":704002,"name":"Bethany Kolbaba‐Kartchner","orcid":"0000-0001-5004-1554","position":2,"is_corresponding":false},{"id":1033370,"name":"Katherine M. Townsend","orcid":"0000-0001-8004-0237","position":3,"is_corresponding":false},{"id":1033371,"name":"Lila P. Halbers","orcid":"0009-0005-4684-3307","position":4,"is_corresponding":false},{"id":249812,"name":"Zi Yao","orcid":"0000-0003-1825-7472","position":5,"is_corresponding":false},{"id":814890,"name":"Caroline K. Brennan","orcid":null,"position":6,"is_corresponding":false},{"id":280791,"name":"Joseph Ivanic","orcid":"0000-0003-2104-7169","position":7,"is_corresponding":false},{"id":881811,"name":"Tanya Hadjian","orcid":"0000-0001-8194-4043","position":8,"is_corresponding":false},{"id":704003,"name":"Jeremy H. Mills","orcid":"0000-0003-2017-1846","position":9,"is_corresponding":false},{"id":280793,"name":"Martin J. Schnermann","orcid":"0000-0002-0503-0116","position":10,"is_corresponding":false},{"id":139834,"name":"Jennifer A. Prescher","orcid":"0000-0002-9250-4702","position":11,"is_corresponding":false},{"id":704001,"name":"Anna Love","orcid":"0000-0001-5657-2858","position":0,"is_corresponding":true}],"reference_count":68,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T01:07:32.611759Z","pmid":"36745536","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}