{"doi":"10.1021/jacs.2c05726","title":"DNA Strand Displacement Driven by Host–Guest Interactions","abstract":"Base-pair-driven toehold-mediated strand displacement (BP-TMSD) is a fundamental concept employed for constructing DNA machines and networks with a gamut of applications─from theranostics to computational devices. To broaden the toolbox of dynamic DNA chemistry, herein, we introduce a synthetic surrogate termed host-guest-driven toehold-mediated strand displacement (HG-TMSD) that utilizes bioorthogonal, cucurbit[7]uril (CB[7]) interactions with guest-linked input sequences. Since control of the strand-displacement process is salient, we demonstrate how HG-TMSD can be finely modulated via changes to the structure of the input sequence (including synthetic guest head-group and/or linker length). Further, for a given input sequence, competing small-molecule guests can serve as effective regulators (with fine and coarse control) of HG-TMSD. To show integration into functional devices, we have incorporated HG-TMSD into machines that control enzyme activity and layered reactions that detect specific microRNA.","journal":"Journal of the American Chemical Society","year":2022,"id":242928,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":36,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.949,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":874587,"name":"Jennifer H. T. Tran","orcid":null,"position":1,"is_corresponding":false},{"id":874588,"name":"Noah Beltrami","orcid":null,"position":2,"is_corresponding":false},{"id":874148,"name":"Kun Meng","orcid":"0000-0002-5272-2828","position":3,"is_corresponding":false},{"id":874149,"name":"Xiao Zhou","orcid":"0000-0003-4491-2573","position":4,"is_corresponding":false},{"id":874150,"name":"Pravin Pathak","orcid":"0000-0003-3657-0008","position":5,"is_corresponding":false},{"id":301914,"name":"Lyle Isaacs","orcid":"0000-0002-4079-332X","position":6,"is_corresponding":false},{"id":874151,"name":"Alexander L. Burin","orcid":"0000-0003-1922-1711","position":7,"is_corresponding":false},{"id":874152,"name":"Mehnaaz Ali","orcid":"0000-0002-4289-5944","position":8,"is_corresponding":false},{"id":874153,"name":"Janarthanan Jayawickramarajah","orcid":"0000-0001-5271-1523","position":9,"is_corresponding":false},{"id":874586,"name":"Dilanka V. D. Walpita Kankanamalage","orcid":null,"position":0,"is_corresponding":true}],"reference_count":73,"raw_metadata":null,"created_at":"2026-07-19T00:23:10.218426Z","pmid":"36063395","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}