{"doi":"10.1021/jacs.2c04571","title":"Degradable ZnS-Supported Bioorthogonal Nanozymes with Enhanced Catalytic Activity for Intracellular Activation of Therapeutics","abstract":"Bioorthogonal catalysis using transition-metal catalysts (TMCs) provides a toolkit for the in situ generation of imaging and therapeutic agents in biological environments. Integrating TMCs with nanomaterials mimics key properties of natural enzymes, providing bioorthogonal “nanozymes”. ZnS nanoparticles provide a platform for bioorthogonal nanozymes using ruthenium catalysts embedded in self-assembled monolayers on the particle surface. These nanozymes uncage allylated profluorophores and prodrugs. The ZnS core combines the non-toxicity and degradability with the enhancement of Ru catalysis through the release of thiolate surface ligands that accelerate the rate-determining step in the Ru-mediated deallylation catalytic cycle. The maximum rate of reaction (Vmax) increases ∼2.5-fold as compared to the non-degradable gold nanoparticle analogue. The therapeutic potential of these bioorthogonal nanozymes is demonstrated by activating a chemotherapy drug from an inactive prodrug with efficient killing of cancer cells.","journal":"Journal of the American Chemical Society","year":2022,"id":236134,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":72,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.94,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":855929,"name":"Shichao Lin","orcid":"0000-0003-3423-6225","position":1,"is_corresponding":false},{"id":382952,"name":"Rui Huang","orcid":"0000-0002-3048-2835","position":2,"is_corresponding":false},{"id":488453,"name":"Aarohi Gupta","orcid":"0000-0003-1303-1159","position":3,"is_corresponding":false},{"id":488452,"name":"Stefano Fedeli","orcid":"0000-0002-1097-6926","position":4,"is_corresponding":false},{"id":262469,"name":"Roberto Cao‐Milán","orcid":"0000-0002-5935-2313","position":5,"is_corresponding":false},{"id":232156,"name":"David C. Luther","orcid":"0000-0002-4697-8683","position":6,"is_corresponding":false},{"id":463382,"name":"Yuanchang Liu","orcid":"0000-0001-9306-297X","position":7,"is_corresponding":false},{"id":426194,"name":"Mingdi Jiang","orcid":"0000-0002-4742-405X","position":8,"is_corresponding":false},{"id":464549,"name":"Gengtan Li","orcid":null,"position":9,"is_corresponding":false},{"id":464551,"name":"Brayan Rondon","orcid":null,"position":10,"is_corresponding":false},{"id":855930,"name":"Hui Wei","orcid":"0000-0003-0870-7142","position":11,"is_corresponding":false},{"id":232161,"name":"Vincent M. Rotello","orcid":"0000-0002-5184-5439","position":12,"is_corresponding":false},{"id":232159,"name":"Xianzhi Zhang","orcid":"0000-0002-9585-7458","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T00:21:58.728756Z","pmid":"35786910","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}