{"doi":"10.1021/jacs.0c04917","title":"Synthesis of 9-Dechlorochrysophaentin A Enables Studies Revealing Bacterial Cell Wall Biosynthesis Inhibition Phenotype in <i>B. subtilis</i>","abstract":"Chrysophaentin A is an antimicrobial natural product isolated from the marine alga C. taylori in milligram quantity. Structurally, chrysophaentin A features a macrocyclic biaryl ether core incorporating two trisubstituted chloroalkenes at its periphery. A concise synthesis of iso- and 9-dechlorochrysophaentin A enabled by a Z-selective ring-closing metathesis (RCM) cyclization followed by an oxygen to carbon ring contraction is described. Fluorescent microscopy studies revealed 9-dechlorochrysophaentins leads to inhibition of bacterial cell wall biosynthesis by disassembly of key divisome proteins, the cornerstone to bacterial cell wall biosynthesis and division.","journal":"Journal of the American Chemical Society","year":2020,"id":84199,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9546,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":432266,"name":"Yen‐Pang Hsu","orcid":"0000-0002-7706-9482","position":1,"is_corresponding":false},{"id":303981,"name":"Ellen M. Quardokus","orcid":"0000-0001-7655-4833","position":2,"is_corresponding":false},{"id":433215,"name":"Gengxiang Zhao","orcid":null,"position":3,"is_corresponding":false},{"id":383504,"name":"Carole A. Bewley","orcid":"0000-0003-2203-0852","position":4,"is_corresponding":false},{"id":308354,"name":"Michael S. VanNieuwenhze","orcid":"0000-0001-6093-5949","position":5,"is_corresponding":false},{"id":317764,"name":"Gary A. Sulikowski","orcid":"0000-0002-1067-0767","position":6,"is_corresponding":false},{"id":432265,"name":"Christopher R. Fullenkamp","orcid":"0000-0002-9479-896X","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-18T21:54:50.827092Z","pmid":"32866011","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}