{"doi":"10.1021/jacs.0c04023","title":"A Stable Ferryl Porphyrin at the Active Site of Y463M BthA","abstract":"BthA is a diheme enzyme that is a member of the bacterial cytochrome c peroxidase superfamily, capable of generating a highly unusual Fe(IV)Fe(IV)═O oxidation state, known to be responsible for long-range oxidative chemistry in the enzyme MauG. Here, we show that installing a canonical Met ligand in lieu of the Tyr found at the heme of MauG associated with electron transfer, results in a construct that yields an unusually stable Fe(IV)═O porphyrin at the peroxidatic heme. This state is spontaneously formed at ambient conditions using either molecular O2 or H2O2. The resulting data illustrate how a ferryl iron, with unforeseen stability, may be achieved in biology.","journal":"Journal of the American Chemical Society","year":2020,"id":108625,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9483,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":461092,"name":"Andrew C. Weitz","orcid":"0000-0002-9001-1103","position":1,"is_corresponding":false},{"id":410106,"name":"Steven E. Cohen","orcid":"0000-0002-3193-0740","position":2,"is_corresponding":false},{"id":241330,"name":"Catherine L. Drennan","orcid":"0000-0001-5486-2755","position":3,"is_corresponding":false},{"id":340417,"name":"Michael P. Hendrich","orcid":"0000-0003-4775-0389","position":4,"is_corresponding":false},{"id":494210,"name":"Sean J. Elliott","orcid":"0000-0003-0096-9551","position":5,"is_corresponding":false},{"id":519739,"name":"Kimberly Rizzolo","orcid":"0000-0001-8335-5154","position":0,"is_corresponding":true}],"reference_count":29,"raw_metadata":null,"created_at":"2026-07-18T23:12:43.081337Z","pmid":"32564595","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}