{"doi":"10.1021/ja512029x","title":"Pd(II)-Catalyzed Enantioselective Synthesis of P-Stereogenic Phosphinamides via Desymmetric C–H Arylation","abstract":null,"journal":"Journal of the American Chemical Society","year":2015,"id":689715,"datarank":0.8208406010507213,"base_score":5.472270673671475,"endowment":5.472270673671475,"self_citation_contribution":0.8208406010507213,"citation_network_contribution":0.0,"self_endowment_contribution":0.8208406010507213,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":237,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":1,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":447933,"name":"Jing Guan","orcid":"0000-0002-4978-2512","position":1,"is_corresponding":false},{"id":1801869,"name":"Guo-Jie Wu","orcid":null,"position":2,"is_corresponding":false},{"id":4389,"name":"Peng Xu","orcid":"0000-0001-8007-9879","position":3,"is_corresponding":false},{"id":1801870,"name":"Lian-Xun Gao","orcid":null,"position":4,"is_corresponding":false},{"id":1801871,"name":"Fu-She Han","orcid":null,"position":5,"is_corresponding":false},{"id":1801868,"name":"Zhi-Jun Du","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Pd(II)-Catalyzed Enantioselective Synthesis of P-Stereogenic Phosphinamides via Desymmetric C–H Arylation","abstract":"We present the enantioselective synthesis of P-stereogenic phosphinamides through Pd-catalyzed desymmetric ortho C-H arylation of diarylphosphinamides with boronic esters. The method represents the first example of the synthesis of P-stereogenic phosphorus compounds via the desymmetric C-H functionalization strategy. The reaction proceeded efficiently with a wide array of reaction partners to afford the P-stereogenic phosphinamides in up to 74% yield and 98% ee. The efficiency was further demonstrated by gram scale syntheses. Moreover, the flexible conversion of the P-stereogenic phosphinamides into various types of P-stereogenic phosphorus derivatives was also elaborated. Thus, the protocol provides a novel tool for the efficient and versatile synthesis of P-stereogenic compounds.","is_dataset_classified":null,"base_score":5.472270673671475,"endowment":5.472270673671475,"datacite_reuse_total":1,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25569141","pmcid":null,"openalex_id":"https://openalex.org/W2313162135","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"21272225","title":null}],"total_grants":1,"fwci":9.7858,"citation_percentile":0.987565,"influential_citations":1,"citation_trend":[{"year":2015,"count":13},{"year":2016,"count":20},{"year":2017,"count":28},{"year":2018,"count":23},{"year":2019,"count":22},{"year":2020,"count":13},{"year":2021,"count":23},{"year":2022,"count":22},{"year":2023,"count":17},{"year":2024,"count":23},{"year":2025,"count":23},{"year":2026,"count":9}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/ja512029x","host_type":"publisher"},{"url":"https://doi.org/10.1021/ja512029x","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25569141","host_type":"repository"}],"fields_of_study":["Asymmetric Hydrogenation and Catalysis","Organophosphorus compounds synthesis","Asymmetric Synthesis and Catalysis","Chemistry","Medicine"],"mesh_terms":[],"keywords":["Stereocenter","Enantioselective synthesis","Chemistry","Catalysis","Stereochemistry","Yield (engineering)","Combinatorial chemistry","Organic chemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[{"doi":"10.5517/cc14c2yj","title":"CCDC 1053347: Experimental Crystal Structure Determination","publisher":"Cambridge Crystallographic Data Centre","resource_type":"Dataset"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-22T14:19:10.013544Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}