{"doi":"10.1021/ci100050t","title":"Extended-Connectivity Fingerprints","abstract":"Extended-connectivity fingerprints (ECFPs) are a novel class of topological fingerprints for molecular characterization. Historically, topological fingerprints were developed for substructure and similarity searching. ECFPs were developed specifically for structure-activity modeling. ECFPs are circular fingerprints with a number of useful qualities: they can be very rapidly calculated; they are not predefined and can represent an essentially infinite number of different molecular features (including stereochemical information); their features represent the presence of particular substructures, allowing easier interpretation of analysis results; and the ECFP algorithm can be tailored to generate different types of circular fingerprints, optimized for different uses. While the use of ECFPs has been widely adopted and validated, a description of their implementation has not previously been presented in the literature.","journal":"Journal of Chemical Information and Modeling","year":2010,"id":5227,"datarank":20.027513254722678,"base_score":8.914491710191342,"endowment":8.914491710191342,"self_citation_contribution":1.3371737565287014,"citation_network_contribution":18.690339498193975,"self_endowment_contribution":1.3371737565287014,"citer_contribution":18.690339498193975,"corpus_percentile":93.1,"corpus_rank":1694,"citation_count":7438,"citer_count":199,"citers_with_citation_signal":199,"citers_with_endowment":199,"datacite_reuse_total":0,"is_dataset":false,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2010-04-28","authors":[{"id":52539,"name":"Mathew Hahn","orcid":null,"position":1,"is_corresponding":false},{"id":52538,"name":"David Rogers","orcid":"0000-0002-5187-1768","position":0,"is_corresponding":true}],"reference_count":107,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-03-01T18:20:47.508186Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}