{"doi":"10.1021/bk-2012-1115.ch012","title":"Galectin-3C: Human Lectin for Treatment of Cancer","abstract":null,"journal":"ACS Symposium Series","year":2012,"id":600175,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1538473,"name":"Leonardo Mirandola","orcid":null,"position":1,"is_corresponding":false},{"id":1538475,"name":"Yu Yuefei","orcid":null,"position":2,"is_corresponding":false},{"id":715359,"name":"Everardo Cobos","orcid":"0000-0001-5799-0074","position":3,"is_corresponding":false},{"id":1538480,"name":"Maurizio Chiriva-Internati","orcid":null,"position":4,"is_corresponding":false},{"id":513846,"name":"Constance M. John","orcid":"0000-0003-4984-6325","position":5,"is_corresponding":false},{"id":438012,"name":"Gary A. Jarvis","orcid":"0000-0002-7576-3702","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Galectin-3C: Human Lectin for Treatment of Cancer","abstract":"A summary is provided of the compelling data supporting galectin-3, as a target for cancer therapy, and for the clinical development of a truncated form of human galectin-3, termed galectin-3C, for cancer. Lacking the N-terminal domain of galectin-3 that facilitates its multimerization when bound to carbohydrate ligands, galectin-3C functions as an inhibitor of the galectin-3 crosslinking mediated by the N-terminal domain that can be induced by multivalent oligosaccharides and glycoconjugates intra- or extracellularly, on cell surfaces, or in extracellular matrices. Numerous studies show that galectin-3 plays a key role in tumorigenicity and metastasis and is a novel target for the development of cancer therapeutics. Data presented indicate that galectin-3C can be localized in a carbohydrate-dependent manner similar to most information reported regarding galectin-3. Exogenous galectin-3C facilitated anoikis in human breast cells, illustrating an effect it is expected to produce in vivo by reducing cell-cell or cell-ECM adhesion of metastatic cells. Based on the activity of galectin-3, we postulate that galectin-3C also inhibits the metastatic process by preventing integrin activation and focal adhesion turnover. The data described provide evidence of the important functions of galectin-3 in the processes of metastasis and tumorigenicity, and the potential therapeutic effect of inhibiting the activity of galectin-3 with galectin-3C. Galectin-3 has a complex, multi-faceted role that is critical in the relationship between the cells of various types of malignancies and the microenvironment, and further development of galectin-3C as a clinical candidate for cancer treatment is warranted.","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21097893","pmcid":null,"openalex_id":"https://openalex.org/W2506475006","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[{"year":2014,"count":2},{"year":2023,"count":1},{"year":2024,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/bk-2012-1115.ch012","host_type":"publisher"},{"url":"https://doi.org/10.1021/bk-2012-1115.ch012","host_type":"book series"}],"fields_of_study":["Galectins and Cancer Biology","Signaling Pathways in Disease","Peptidase Inhibition and Analysis"],"mesh_terms":[],"keywords":["Galectin","Galectin-3","Galectin-1","Glycoconjugate","Metastasis","Cell adhesion","Cancer cell","Cell biology","Lectin","Cancer research","Anoikis","Chemistry","Cell","Cancer","Biology","Biochemistry","Immunology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T12:24:06.833098Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}