{"doi":"10.1021/bi100430s","title":"Na<sup>+</sup>:Aspartate Coupling Stoichiometry in the Glutamate Transporter Homologue Glt<sub>Ph</sub>","abstract":null,"journal":"Biochemistry","year":2010,"id":681053,"datarank":0.6952093482344455,"base_score":4.634728988229636,"endowment":4.634728988229636,"self_citation_contribution":0.6952093482344455,"citation_network_contribution":0.0,"self_endowment_contribution":0.6952093482344455,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":102,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1779393,"name":"Dirk-Jan Slotboom","orcid":null,"position":1,"is_corresponding":false},{"id":1779391,"name":"Maarten Groeneveld","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Na<sup>+</sup>:Aspartate Coupling Stoichiometry in the Glutamate Transporter Homologue Glt<sub>Ph</sub>","abstract":"The Na(+) aspartate symporter Glt(Ph) from Pyrococcus horikoshii is the only member of the glutamate transporter family for which crystal structures have been determined. The cation:aspartate coupling stoichiometry is unknown, thus hampering the elucidation of the ion coupling mechanism. Here we measure transport of (22)Na(+) and [(14)C]aspartate in proteoliposomes containing purified Glt(Ph) and demonstrate that three Na(+) ions are symported with aspartate.","is_dataset_classified":null,"base_score":4.634728988229636,"endowment":4.634728988229636,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20349989","pmcid":null,"openalex_id":"https://openalex.org/W2097935452","authors":[],"funders":[],"total_grants":0,"fwci":3.5897,"citation_percentile":0.94083513,"influential_citations":4,"citation_trend":[{"year":2012,"count":8},{"year":2013,"count":16},{"year":2014,"count":8},{"year":2015,"count":11},{"year":2016,"count":7},{"year":2017,"count":8},{"year":2018,"count":2},{"year":2019,"count":7},{"year":2020,"count":11},{"year":2021,"count":10},{"year":2022,"count":1},{"year":2023,"count":1},{"year":2024,"count":2},{"year":2025,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/bi100430s","host_type":"publisher"},{"url":"https://doi.org/10.1021/bi100430s","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20349989","host_type":"repository"},{"url":"https://research.rug.nl/en/publications/108d68b7-618d-4e28-a27c-5c07199ad814","host_type":"repository"},{"url":"https://hdl.handle.net/11370/108d68b7-618d-4e28-a27c-5c07199ad814","host_type":"repository"}],"fields_of_study":["Neuroscience and Neuropharmacology Research","Photoreceptor and optogenetics research","Molecular Sensors and Ion Detection","Medicine","Chemistry","Biology","Amino Acid Transport System X-AG","Aspartic Acid","Biological Transport","Protein Conformation","Proteolipids","Pyrococcus horikoshii","Sodium"],"mesh_terms":["Aspartic Acid","Biological Transport","Protein Conformation","Proteolipids","Sodium","Amino Acid Transport System X-AG","Pyrococcus horikoshii"],"keywords":["Pyrococcus horikoshii","Symporter","Chemistry","Stoichiometry","Transporter","Glutamate aspartate transporter","Excitatory amino-acid transporter","Coupling (piping)","Glutamate receptor","Ion","Crystallography","Crystal structure","Biochemistry","Materials science","Physical chemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T16:50:31.221919Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}