{"doi":"10.1021/bi049957v","title":"Temperature-Dependent Intermediates in HIV-1 Envelope Glycoprotein-Mediated Fusion Revealed by Inhibitors that Target N- and C-Terminal Helical Regions of HIV-1 gp41","abstract":null,"journal":"Biochemistry","year":2004,"id":596289,"datarank":0.47670807455219194,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.0,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":57566,"name":"G. Marius Clore","orcid":"0000-0003-3809-1027","position":1,"is_corresponding":false},{"id":458319,"name":"John M. Louis","orcid":"0000-0002-0052-1899","position":2,"is_corresponding":false},{"id":383504,"name":"Carole A. Bewley","orcid":"0000-0003-2203-0852","position":3,"is_corresponding":false},{"id":356768,"name":"Robert Blumenthal","orcid":"0000-0002-0873-0724","position":4,"is_corresponding":false},{"id":795981,"name":"Stephen A. Gallo","orcid":"0000-0001-6043-2153","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Temperature-Dependent Intermediates in HIV-1 Envelope Glycoprotein-Mediated Fusion Revealed by Inhibitors that Target N- and C-Terminal Helical Regions of HIV-1 gp41","abstract":"Peptides derived from the N- (N-HR) and C- (C-HR) terminal heptad repeat regions adjacent to the fusion peptide and transmembrane domains, respectively, of human immunodeficiency virus (HIV)-1 gp41 inhibit HIV-1 viral envelope glycoproteins (Env)-mediated cell fusion specifically. The mechanism of HIV-1 Env-mediated cell fusion and its inhibition by agents that target the N- and C-HR regions was investigated. Priming experiments with Env-expressing cells indicate that the N-HR region but not the C-HR region is exposed by treatment with sCD4 at 31 degrees C, whereas both the N- and C-HR regions are exposed at 37 degrees C.","is_dataset_classified":null,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15209519","pmcid":null,"openalex_id":"https://openalex.org/W2051731457","authors":[],"funders":[],"total_grants":0,"fwci":1.2213,"citation_percentile":0.75127291,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2021,"count":2},{"year":2023,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/bi049957v","host_type":"publisher"},{"url":"https://doi.org/10.1021/bi049957v","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15209519","host_type":"repository"}],"fields_of_study":["HIV Research and Treatment","RNA and protein synthesis mechanisms","HIV/AIDS drug development and treatment","Amino Acid Sequence","Animals","CD4 Antigens","CHO Cells","Cell Line","Cricetinae","Cricetulus","HIV Envelope Protein gp41","HIV Fusion Inhibitors","HIV-1","HeLa Cells","Humans","Membrane Fusion","Mice","Molecular Sequence Data","NIH 3T3 Cells","Peptide Fragments","Protein Structure, Secondary","Receptors, CXCR4","Temperature"],"mesh_terms":["Amino Acid Sequence","Animals","Cell Line","Cricetulus","Cricetinae","HeLa Cells","Humans","Membrane Fusion","Molecular Sequence Data","Peptide Fragments","Temperature","HIV-1","HIV Envelope Protein gp41","CD4 Antigens","CHO Cells","Protein Structure, Secondary","Receptors, CXCR4","HIV Fusion Inhibitors","NIH 3T3 Cells","Mice","Hela Cells"],"keywords":["Gp41","Human immunodeficiency virus (HIV)","Glycoprotein","Terminal (telecommunication)","Fusion","Envelope (radar)","Chemistry","Stereochemistry","Virology","Biochemistry","Biology","Genetics","Antigen","Computer science","Philosophy","Epitope"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-28T09:41:32.313063Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}