{"doi":"10.1021/bi010176t","title":"Erythrocyte Spectrin Is an E2 Ubiquitin Conjugating Enzyme","abstract":null,"journal":"Biochemistry","year":2001,"id":592367,"datarank":0.8422919688380341,"base_score":3.044522437723423,"endowment":3.044522437723423,"self_citation_contribution":0.4566783656585135,"citation_network_contribution":0.38561360317952065,"self_endowment_contribution":0.4566783656585135,"citer_contribution":0.38561360317952065,"corpus_percentile":null,"corpus_rank":null,"citation_count":20,"citer_count":11,"citers_with_citation_signal":10,"citers_with_endowment":10,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1515752,"name":"Tanuja Chaudhary","orcid":null,"position":1,"is_corresponding":false},{"id":595056,"name":"Warren E. Zimmer","orcid":"0000-0002-0668-6096","position":2,"is_corresponding":false},{"id":1515753,"name":"F. Aladar Bencsath","orcid":null,"position":3,"is_corresponding":false},{"id":195256,"name":"Ian Jardine","orcid":null,"position":4,"is_corresponding":false},{"id":1515754,"name":"Steven R. Goodman","orcid":null,"position":5,"is_corresponding":false},{"id":1515751,"name":"David G. Kakhniashvili","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Erythrocyte Spectrin Is an E2 Ubiquitin Conjugating Enzyme","abstract":"The involvement of red blood cell spectrin in the ubiquitination process was studied. Spectrin was found to form two ubiquitin-associated derivatives, a DTT-sensitive ubiquitin adduct and a DTT-insensitive conjugate, characteristic intermediate and final products of the ubiquitination reaction cascade. In addition to spectrin and ubiquitin, ubiquitin-activating enzyme (E1) and ATP were necessary and sufficient to form both the spectrin-ubiquitin adduct and conjugate. No exogenous ubiquitin-conjugating (E2) or ligase (E3) activities were required, suggesting that erythrocyte spectrin is an E2 ubiquitin-conjugating enzyme able to target itself. Both ubiquitin adduct and conjugate were linked to the alpha subunit of spectrin, suggesting that the ubiquitin-conjugating (UBC) domain and its target regions reside on the same subunit.","is_dataset_classified":null,"base_score":3.044522437723423,"endowment":3.044522437723423,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"11560514","pmcid":null,"openalex_id":"https://openalex.org/W2041022871","authors":[],"funders":[{"funder_name":"NHLBI NIH HHS","grant_id":"3P60HL38635","title":null}],"total_grants":1,"fwci":0.3079,"citation_percentile":0.56372998,"influential_citations":0,"citation_trend":[{"year":2013,"count":2},{"year":2015,"count":2},{"year":2016,"count":1},{"year":2018,"count":1},{"year":2019,"count":2},{"year":2020,"count":1},{"year":2022,"count":1},{"year":2025,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/bi010176t","host_type":"publisher"},{"url":"https://doi.org/10.1021/bi010176t","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/11544658","host_type":"repository"},{"url":"https://pubmed.ncbi.nlm.nih.gov/11560514","host_type":"repository"}],"fields_of_study":["Erythrocyte Function and Pathophysiology","Autophagy in Disease and Therapy","Neonatal Health and Biochemistry","Adenosine Triphosphate","Amino Acid Sequence","Electrophoresis, Polyacrylamide Gel","Erythrocyte Membrane","Humans","Ligases","Mass Spectrometry","Molecular Sequence Data","Molecular Weight","Peptide Fragments","Spectrin","Ubiquitin-Conjugating Enzymes","Ubiquitins"],"mesh_terms":["Erythrocyte Membrane","Humans","Ligases","Ubiquitin-Conjugating Enzymes","Peptide Fragments","Spectrin","Ubiquitins","Adenosine Triphosphate","Electrophoresis, Polyacrylamide Gel","Amino Acid Sequence","Molecular Weight","Molecular Sequence Data","Mass Spectrometry"],"keywords":["Ubiquitin","Spectrin","Ubiquitin-conjugating enzyme","Ubiquitin ligase","Ubiquitins","Deubiquitinating enzyme","Conjugate","Biochemistry","Chemistry","Protein subunit","Ubiquitin-Protein Ligases","Enzyme","Molecular biology","Biology","Cell","Gene","Cytoskeleton"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T13:22:46.998437Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}