{"doi":"10.1021/bi00252a026","title":"Biophysical characterization of the c-myb DNA-binding domain","abstract":null,"journal":"Biochemistry","year":1994,"id":643059,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1672990,"name":"Olaf Schweers","orcid":null,"position":1,"is_corresponding":false},{"id":1672991,"name":"Hubert Thole","orcid":null,"position":2,"is_corresponding":false},{"id":1672992,"name":"Ursula Fagin","orcid":null,"position":3,"is_corresponding":false},{"id":1672993,"name":"Claus Urbanke","orcid":null,"position":4,"is_corresponding":false},{"id":1672994,"name":"Guenther Maass","orcid":null,"position":5,"is_corresponding":false},{"id":1672995,"name":"Heiner Wolfes","orcid":null,"position":6,"is_corresponding":false},{"id":1672989,"name":"Andreas Ebneth","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Biophysical characterization of the c-myb DNA-binding domain","abstract":"We have examined proteins containing the DNA-binding domain of c-Myb with biophysical methods. This DNA-binding domain consists of three imperfect repeats (R1, R2, and R3) conserved among many species. Our results indicate that the DNA-binding domain forms unspecific and specific complexes with oligodeoxynucleotides. In the presence of R1, DNA sequences related to a canonical c-Myb-binding site are better discriminated. Furthermore, although R2 and R3 are sufficient for sequence-specific DNA binding, a structural change of the DNA-binding domain upon specific complex formation is induced only when R1 is present. Therefore, R1 might serve as an important element required for secondary structure alteration upon binding and its stabilization as well as for better discrimination between specific and related DNA sequences.","is_dataset_classified":null,"base_score":2.772588722239781,"endowment":2.772588722239781,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"7981220","pmcid":null,"openalex_id":"https://openalex.org/W2041583538","authors":[],"funders":[],"total_grants":0,"fwci":1.9243,"citation_percentile":0.82224248,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/bi00252a026","host_type":"publisher"},{"url":"https://doi.org/10.1021/bi00252a026","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/7981220","host_type":"repository"}],"fields_of_study":["Bioactive Compounds and Antitumor Agents","Cancer therapeutics and mechanisms","Base Sequence","Biophysical Phenomena","Biophysics","Circular Dichroism","DNA-Binding Proteins","Deoxyribonucleoproteins","In Vitro Techniques","Molecular Sequence Data","Oligodeoxyribonucleotides","Polymerase Chain Reaction","Protein Structure, Secondary","Proto-Oncogene Proteins","Proto-Oncogene Proteins c-myb","Recombinant Proteins","Trypsin","Ultracentrifugation"],"mesh_terms":["Base Sequence","Biophysics","Circular Dichroism","Deoxyribonucleoproteins","DNA-Binding Proteins","Molecular Sequence Data","Oligodeoxyribonucleotides","Proto-Oncogene Proteins","Recombinant Proteins","Trypsin","Ultracentrifugation","Polymerase Chain Reaction","Protein Structure, Secondary","Proto-Oncogene Proteins c-myb","Biophysical Phenomena","In Vitro Techniques"],"keywords":["Citation","Social media","Computer science","Icon","Information retrieval","Altmetrics","World Wide Web","Library science"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Reduced inequalities"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-08T12:17:26.515469Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}