{"doi":"10.1021/acsptsci.1c00219","title":"Experimental Model of Pulmonary Inflammation Induced by SARS-CoV-2 Spike Protein and Endotoxin","abstract":null,"journal":"ACS Pharmacology & Translational Science","year":2022,"id":610343,"datarank":0.44166584687496613,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.0,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":898174,"name":"Lloyd Tanner","orcid":"0000-0003-0626-9820","position":1,"is_corresponding":false},{"id":1569218,"name":"Ganna Petruk","orcid":null,"position":2,"is_corresponding":false},{"id":1569220,"name":"Artur Schmidtchen","orcid":"0000-0001-9209-3141","position":3,"is_corresponding":false},{"id":1569215,"name":"Manoj Puthia","orcid":"0000-0001-6048-7234","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Experimental Model of Pulmonary Inflammation Induced by SARS-CoV-2 Spike Protein and Endotoxin","abstract":"COVID-19 is characterized by a dysregulated and excessive inflammatory response and, in severe cases, acute respiratory distress syndrome. We have recently demonstrated a previously unknown high-affinity interaction between the SARS-CoV-2 spike (S) protein and bacterial lipopolysaccharide (LPS), leading to the boosting of inflammation. Here we present a mouse inflammation model employing the coadministration of aerosolized S protein together with LPS to the lungs. Using NF-κB-RE-Luc reporter and C57BL/6 mice followed by combinations of bioimaging, cytokine, chemokine, fluorescence-activated cell sorting, and histochemistry analyses, we show that the model yields severe pulmonary inflammation and a cytokine profile similar to that observed in COVID-19. Therefore, the model offers utility for analyses of the pathophysiological features of COVID-19 and the development of new treatments.","is_dataset_classified":null,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35774232","pmcid":"PMC9239546","openalex_id":"https://openalex.org/W4207037848","authors":[],"funders":[{"funder_name":"Vetenskapsr?det","grant_id":"2017-02341","title":null},{"funder_name":"Vetenskapsr?det","grant_id":"2020-02016","title":null},{"funder_name":"Alfred ?sterlunds Stiftelse","grant_id":"","title":null},{"funder_name":"Crafoordska Stiftelsen","grant_id":"","title":null},{"funder_name":"Kungliga Fysiografiska S?llskapet i Lund","grant_id":"","title":null},{"funder_name":"Edvard Welanders Stiftelse","grant_id":"","title":null},{"funder_name":"Swedish Government Funds for Clinical Research","grant_id":"","title":null},{"funder_name":"Finsenstiftelsen","grant_id":"","title":null},{"funder_name":"Stiftelsen Lars Hiertas Minne","grant_id":"","title":null},{"funder_name":"Torsten S?derbergs Stiftelse","grant_id":"","title":null}],"total_grants":10,"fwci":1.6422,"citation_percentile":0.84929241,"influential_citations":0,"citation_trend":[{"year":2022,"count":3},{"year":2023,"count":9},{"year":2024,"count":3},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"hybrid","license":"cc-by","oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/acsptsci.1c00219","host_type":"journal"},{"url":"https://pubs.acs.org/doi/pdf/10.1021/acsptsci.1c00219","host_type":"publisher"},{"url":"https://doi.org/10.1021/acsptsci.1c00219","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35774232","host_type":"repository"},{"url":"https://lup.lub.lu.se/record/50ecf9d2-4e5c-4fe9-befa-f7a7e16cf218","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9239546","host_type":"repository"},{"url":"https://researchprofiles.ku.dk/da/publications/fe27aeb3-9832-44a4-87c8-6c6fcc71df03","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9239546","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9239546?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["COVID-19 Clinical Research Studies","Respiratory Support and Mechanisms","SARS-CoV-2 and COVID-19 Research"],"mesh_terms":[],"keywords":["Inflammation","Lipopolysaccharide","Chemokine","Cytokine","Immunology","ARDS","Boosting (machine learning)","Tumor necrosis factor alpha","Pneumonia","Coronavirus","Medicine","Coronavirus disease 2019 (COVID-19)","Biology","Lung","Pathology","Internal medicine"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-31T21:27:27.611789Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}