{"doi":"10.1021/acsptsci.1c00184","title":"Electron Donors Rather Than Reactive Oxygen Species Needed for Therapeutic Photochemical Reaction of Near-Infrared Photoimmunotherapy","abstract":"Near-infrared photoimmunotherapy (NIR-PIT) employs molecularly targeted antibodies conjugated with a photoabsorbing silicon-phthalocyanine dye derivative which binds to cancer cells. Application of NIR light following binding of the antibody-photoabsorber conjugates (APCs) results in ligand release on the dye, dramatic changes in solubility of the APC-antigen complex, and rapid, irreversible cell membrane damage of cancer cells in a highly selective manner, resulting in a highly immunogenic cell death. Clinically, this process results in edema after treatment mediated by reactive oxygen species (ROS). Based on the chemical and biological mechanism of NIR-PIT cytotoxicity and edema formation, in order to minimize acute inflammatory edema without compromising therapeutic effects, l-sodium ascorbate (l-NaAA) was administered to quench harmful ROS and accelerate the ligand release reaction. l-NaAA suppressed acute edema by reducing ROS after NIR-PIT yet did not alter the therapeutic effects. NIR-PIT could be performed safely under existence of l-NaAA without side effects caused by unnecessary ROS production.","journal":"ACS Pharmacology & Translational Science","year":2021,"id":168126,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9483,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":296180,"name":"Ryuhei Okada","orcid":"0000-0003-3589-5054","position":1,"is_corresponding":false},{"id":696705,"name":"Yuto Goto","orcid":"0000-0003-3898-2831","position":2,"is_corresponding":false},{"id":262825,"name":"Aki Furusawa","orcid":"0000-0002-1339-4219","position":3,"is_corresponding":false},{"id":296181,"name":"Fuyuki Inagaki","orcid":"0000-0002-9953-3805","position":4,"is_corresponding":false},{"id":296182,"name":"Hiroaki Wakiyama","orcid":"0000-0001-6388-9888","position":5,"is_corresponding":false},{"id":691989,"name":"Hideyuki Furumoto","orcid":"0000-0002-5000-4283","position":6,"is_corresponding":false},{"id":697360,"name":"Dagane Daar","orcid":null,"position":7,"is_corresponding":false},{"id":110339,"name":"Barış Türkbey","orcid":"0000-0003-0853-6494","position":8,"is_corresponding":false},{"id":110328,"name":"Peter L. Choyke","orcid":"0000-0003-1086-8826","position":9,"is_corresponding":false},{"id":696706,"name":"Hideo Takakura","orcid":"0000-0003-3696-6109","position":10,"is_corresponding":false},{"id":696707,"name":"Osamu Inanami","orcid":"0000-0001-7895-3918","position":11,"is_corresponding":false},{"id":696708,"name":"Mikako Ogawa","orcid":"0000-0002-3432-4519","position":12,"is_corresponding":false},{"id":262824,"name":"Hisataka Kobayashi","orcid":"0000-0003-1019-4112","position":13,"is_corresponding":false},{"id":296183,"name":"Takuya Kato","orcid":"0000-0003-0673-1077","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-18T23:46:02.603031Z","pmid":"34661083","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}