{"doi":"10.1021/acsomega.2c02369","title":"<sup>68</sup>Ga-Labeled Benzothiazole Derivatives for Imaging Aβ Plaques in Cerebral Amyloid Angiopathy","abstract":"Timely diagnostic imaging plays a crucial role in managing cerebral amyloid angiopathy (CAA)─the condition in which amyloid β is deposited on blood vessels. To selectively map these amyloid plaques, we have designed amyloid-targeting ligands that can effectively complex with 68Ga3+ while maintaining good affinity for amyloid β. In this study, we introduced novel 1,4,7-triazacyclononane-based bifunctional chelators (BFCs) that incorporate a benzothiazole moiety as the Aβ-binding fragment and form charged and neutral species with 68Ga3+. In vitro autoradiography using 5xFAD and WT mouse brain sections (11-month-old) suggested strong and specific binding of the 68Ga complexes to amyloid β. Biodistribution studies in CD-1 mice revealed a low brain uptake of 0.10–0.33% ID/g, thus suggesting 68Ga-labeled novel BFCs as promising candidates for detecting CAA.","journal":"ACS Omega","year":2022,"id":281410,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9402,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":432383,"name":"Yujue Wang","orcid":"0000-0001-6321-9542","position":1,"is_corresponding":false},{"id":820928,"name":"Karna Terpstra","orcid":null,"position":2,"is_corresponding":false},{"id":351633,"name":"Hong‐Jun Cho","orcid":"0000-0002-5358-6549","position":3,"is_corresponding":false},{"id":325450,"name":"Liviu M. Mirica","orcid":"0000-0003-0584-9508","position":4,"is_corresponding":false},{"id":227900,"name":"Buck E. Rogers","orcid":"0000-0001-8189-1797","position":5,"is_corresponding":false},{"id":588250,"name":"Truc T. Huynh","orcid":"0000-0001-6423-6715","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T00:29:11.698554Z","pmid":"35721913","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}