{"doi":"10.1021/acsomega.0c05591","title":"Using Bibliometric Analysis and Machine Learning to Identify Compounds Binding to Sialidase-1","abstract":"8.88 ± 4.02 μM), which validated our approach to identifying new molecules binding to this protein, which could represent possible drug candidates that can be evaluated further as potential chaperones for this ultrarare lysosomal disease for which there is currently no treatment. Combining bibliometric and machine learning approaches has the ability to assist in curating small molecule data and model building, respectively, for rare disease drug discovery. This approach also has the capability to identify new compounds that are potential drug candidates.","journal":"ACS Omega","year":2021,"id":181821,"datarank":0.41588830833596724,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.0,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9418,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":272340,"name":"Nancy Baker","orcid":"0000-0002-8351-9435","position":1,"is_corresponding":false},{"id":414275,"name":"Daniel H. Foil","orcid":"0000-0003-0512-8997","position":2,"is_corresponding":false},{"id":462500,"name":"Kimberley M. Zorn","orcid":null,"position":3,"is_corresponding":false},{"id":327705,"name":"Fabio Urbina","orcid":null,"position":4,"is_corresponding":false},{"id":554234,"name":"Ana C. Puhl","orcid":"0000-0002-1456-8882","position":5,"is_corresponding":false},{"id":272341,"name":"Sean Ekins","orcid":"0000-0002-5691-5790","position":6,"is_corresponding":false},{"id":732943,"name":"Jennifer J. Klein","orcid":"0000-0003-1739-132X","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:48:05.146883Z","pmid":"33553934","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}