{"doi":"10.1021/acsnano.4c06930","title":"Targeting Metastasis in Head and Neck Squamous Cell Carcinoma Using Follistatin mRNA Lipid Nanoparticles","abstract":"Metastatic progression significantly reduces survival rates and complicates treatment strategies in various cancers. Our study introduces an mRNA therapy for metastasis inhibition by targeting activin A overexpression, a pivotal driver of metastasis and cachexia. Utilizing follistatin mRNA lipid nanoparticles, we effectively downregulated activin A both locally in the tumor environment and systemically. This led to a reduction in tumor burden and suppression of metastatic spread in a murine head and neck squamous cell carcinoma model. Treated mice exhibited minimal metastatic occurrence compared to controls. Additionally, our therapy preserved the cross-sectional area of muscle fibers and adipose tissues, combating the muscle and fat wasting typically observed in cancer-associated cachexia. The therapy also demonstrated a favorable safety profile, underscoring its potential for clinical translation. By integrating metastasis-suppressing and cachexia-alleviating mechanisms, our approach represents a promising advancement in comprehensive cancer management. Considering the widespread upregulation of activin A in many cancer types, our therapy holds considerable potential for application across a broad spectrum of oncologic treatments.","journal":"ACS Nano","year":2024,"id":437474,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9565,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":304331,"name":"Tetiana Korzun","orcid":"0000-0002-5871-2778","position":1,"is_corresponding":false},{"id":304328,"name":"Abraham S. Moses","orcid":"0000-0002-7006-5681","position":2,"is_corresponding":false},{"id":572384,"name":"Antony Jozić","orcid":"0000-0001-6249-2328","position":3,"is_corresponding":false},{"id":325375,"name":"Xinxia Zhu","orcid":"0009-0009-4041-1561","position":4,"is_corresponding":false},{"id":504512,"name":"Jeonghwan Kim","orcid":"0000-0002-1697-5107","position":5,"is_corresponding":false},{"id":482401,"name":"Samuel S. Newton","orcid":"0000-0003-0525-1565","position":6,"is_corresponding":false},{"id":504514,"name":"Yulia Eygeris","orcid":"0000-0002-8927-5128","position":7,"is_corresponding":false},{"id":1117248,"name":"Parham Diba","orcid":"0000-0003-1014-510X","position":8,"is_corresponding":false},{"id":645769,"name":"Ariana Sattler","orcid":"0000-0003-1699-4743","position":9,"is_corresponding":false},{"id":633475,"name":"Peter R. Levasseur","orcid":null,"position":10,"is_corresponding":false},{"id":632201,"name":"Brennan Olson","orcid":"0000-0003-2803-5363","position":11,"is_corresponding":false},{"id":1207919,"name":"Ngoc Le","orcid":null,"position":12,"is_corresponding":false},{"id":888168,"name":"Prem Singh","orcid":"0000-0002-0642-9823","position":13,"is_corresponding":false},{"id":1132161,"name":"Kongbrailatpam Shitaljit Sharma","orcid":null,"position":14,"is_corresponding":false},{"id":1207920,"name":"Yoon Tae Goo","orcid":null,"position":15,"is_corresponding":false},{"id":288426,"name":"Babak Mamnoon","orcid":"0000-0002-6413-3879","position":16,"is_corresponding":false},{"id":1207921,"name":"Constanze Raitmayr","orcid":null,"position":17,"is_corresponding":false},{"id":1207922,"name":"Ana Paula Mesquita Souza","orcid":null,"position":18,"is_corresponding":false},{"id":304329,"name":"Olena Taratula","orcid":"0000-0001-8657-036X","position":19,"is_corresponding":false},{"id":249765,"name":"Gaurav Sahay","orcid":"0000-0003-1071-0500","position":21,"is_corresponding":false},{"id":325377,"name":"Daniel L. Marks","orcid":"0000-0003-2675-7047","position":22,"is_corresponding":false},{"id":304336,"name":"Oleh Taratula","orcid":"0000-0002-6227-9110","position":23,"is_corresponding":false},{"id":1207918,"name":"Vladislav Grigoriev","orcid":null,"position":0,"is_corresponding":true}],"reference_count":76,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:00:29.872940Z","pmid":"39569532","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}