{"doi":"10.1021/acsinfecdis.9b00384","title":"Subgenomic RNA from Dengue Virus Type 2 Suppresses Replication of Dengue Virus Genomes and Interacts with Virus-Encoded NS3 and NS5 Proteins","abstract":null,"journal":"ACS Infectious Diseases","year":2020,"id":647587,"datarank":0.8057512293304073,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":0.35639138829730865,"self_endowment_contribution":0.4493598410330987,"citer_contribution":0.35639138829730865,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":14,"citers_with_citation_signal":10,"citers_with_endowment":10,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1177875,"name":"Kitti Wing Ki Chan","orcid":"0000-0002-9326-1853","position":1,"is_corresponding":false},{"id":1687302,"name":"Kishore B. Naripogu","orcid":null,"position":2,"is_corresponding":false},{"id":1687303,"name":"Crystall M. D. Swarbrick","orcid":null,"position":3,"is_corresponding":false},{"id":1687304,"name":"John Aaskov","orcid":null,"position":4,"is_corresponding":false},{"id":1177877,"name":"Subhash G. Vasudevan","orcid":"0000-0002-5083-3831","position":5,"is_corresponding":false},{"id":702416,"name":"Sai Wang","orcid":"0000-0003-1735-6516","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Subgenomic RNA from Dengue Virus Type 2 Suppresses Replication of Dengue Virus Genomes and Interacts with Virus-Encoded NS3 and NS5 Proteins","abstract":"Viral defective interfering particles (DIPs) with more than 90% of the genomic RNA (gRNA, ∼11 000 nucleotides) deleted have been detected in sera from dengue patients. The DIP RNA contains stem-loop structures in the 5′ and 3′ end, which may permit RNA replication in the same manner as dengue virus (DENV) gRNA. Transfection of DENV2 infected human hepatoma cells with DIP RNA (DIP-296) resulted in significant inhibition of virus replication. DIP-296 RNA inhibited DENV replication in a dose-dependent manner in several cell lines tested. The mechanism of inhibition by DIP RNA is unclear; however, our studies imply that the retinoic acid-inducible gene 1 (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) mediated innate immune antiviral signaling pathways and direct interactions of DIP RNA with viral replication proteins may be involved. The latter is supported by in vitro RNA electrophoretic mobility shift assays (REMSAs), which show that DIP RNA can bind directly to the DENV nonstructural proteins NS3 and NS5.","is_dataset_classified":null,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31922712","pmcid":null,"openalex_id":"https://openalex.org/W3000186656","authors":[],"funders":[{"funder_name":"Defense Advanced Research Projects Agency","grant_id":"HR0011-17-2-0036","title":null},{"funder_name":"National Medical Research Council","grant_id":"NMRC/CBRG/0103/2016","title":null},{"funder_name":"Ministry of Health -Singapore","grant_id":"MOH-OFIRG18may-0006/2019","title":null}],"total_grants":3,"fwci":2.5664,"citation_percentile":0.90170836,"influential_citations":0,"citation_trend":[{"year":2020,"count":1},{"year":2021,"count":7},{"year":2022,"count":3},{"year":2023,"count":4},{"year":2026,"count":3}],"oa_status":"gold","license":"other-oa","oa_locations":[{"url":"http://hdl.handle.net/10072/393496","host_type":""},{"url":"http://hdl.handle.net/10072/393496","host_type":""},{"url":"https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.9b00384","host_type":"publisher"},{"url":"https://doi.org/10.1021/acsinfecdis.9b00384","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31922712","host_type":"repository"}],"fields_of_study":["Mosquito-borne diseases and control","Viral Infections and Vectors","Insect symbiosis and bacterial influences"],"mesh_terms":["DEAD Box Protein 58","Interferon-Induced Helicase, IFIH1","Viral Proteases","Cell Line","Defective Viruses","Dengue Virus","Humans","Immunity, Innate","Protein Binding","Receptors, Immunologic","RNA, Viral","Serine Endopeptidases","Virus Replication","Genome, Viral","Viral Nonstructural Proteins"],"keywords":["Virology","Subgenomic mRNA","Dengue virus","NS3","Dengue fever","Virus","Biology","Flavivirus","Antibody-dependent enhancement","Viral replication","Genome","RNA","Hepatitis C virus","Gene","Genetics","Nonstructural protein NS3","innate immunity","Genome Replication","Defective Interfering Particle","Nonstructural Protein Ns5"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T01:28:14.949184Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}