{"doi":"10.1021/acsinfecdis.4c00075","title":"Preclinical Positron Emission Tomography (PET) of Prosthetic Joint Infection Using a Nitro-Prodrug of 2-[<sup>18</sup>F]F-<i>p</i>-Aminobenzoic Acid ([<sup>18</sup>F]F-PABA)","abstract":"Deep-seated bacterial infections are difficult to detect and diagnose due to the lack of specific clinical imaging modalities. Therefore, the bacteria-specific positron emission tomography radiotracer 2-[ 18 F]fluoro-4-nitrobenzoic acid ([ 18 F]FNB) was developed, which is reduced to 2-[ 18 F]fluoro-4-aminobenzoic acid ([ 18 F]F-PABA) by bacterial nitroreductases and has improved pharmacokinetics compared to the parent compound. PET imaging demonstrated that the uptake of 2-[ 18 F]fluoro-4-nitrobenzoic acid in a clinically relevant Staphylococcus aureus prosthetic joint infection model was up to ∼4-fold higher in the infected joint compared to the contralateral joint. 2-[ 18 F]Fluoro-4-nitrobenzoic acid was also able to distinguish infection from inflammation in a surgical inflammation model. Based on the mouse radiation dosimetry results, the calculated effective dose of 2-[ 18 F]fluoro-4-nitrobenzoic acid was well below the whole-body radiation dose limit established by the Food and Drug Administration for humans. In addition, no treatment-related microscopic changes in organ histopathology were observed in a mouse acute toxicity study. Overall, these data suggest that 2-[ 18 F]fluoro-4-nitrobenzoic acid is a specific and effective imaging agent for noninvasively diagnosing prosthetic joint infections.","journal":"ACS Infectious Diseases","year":2024,"id":461518,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9577,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1256723,"name":"Kaixuan Li","orcid":"0000-0001-5244-383X","position":1,"is_corresponding":false},{"id":1290457,"name":"Yong Li","orcid":"0000-0002-0814-3546","position":2,"is_corresponding":false},{"id":1019569,"name":"Shin Hye Ahn","orcid":"0000-0003-4700-4861","position":3,"is_corresponding":false},{"id":1290458,"name":"Mingqian Wang","orcid":"0000-0002-1341-6051","position":4,"is_corresponding":false},{"id":1291017,"name":"Melike Akoglu","orcid":null,"position":5,"is_corresponding":false},{"id":778199,"name":"Eduardo Bravo","orcid":"0000-0001-9209-841X","position":6,"is_corresponding":false},{"id":1291018,"name":"Francesca DelloRusso","orcid":null,"position":7,"is_corresponding":false},{"id":1148876,"name":"Hari K. Akula","orcid":null,"position":8,"is_corresponding":false},{"id":431006,"name":"Wenchao Qü","orcid":"0000-0003-3107-7281","position":9,"is_corresponding":false},{"id":1291019,"name":"Labros G. Meimetis","orcid":null,"position":10,"is_corresponding":false},{"id":769851,"name":"David J. Schlyer","orcid":null,"position":11,"is_corresponding":false},{"id":430660,"name":"David E. Komatsu","orcid":"0000-0002-2618-9492","position":12,"is_corresponding":false},{"id":22118,"name":"Peter J. Tonge","orcid":"0000-0003-1606-3471","position":13,"is_corresponding":false},{"id":1291016,"name":"Alyssa C. Pollard-Kerning","orcid":null,"position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:04:16.410510Z","pmid":"39432749","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}