{"doi":"10.1021/acschembio.1c00227","title":"Identification of a <i>C</i>-Glycosyltransferase Involved in Medermycin Biosynthesis","abstract":null,"journal":"ACS Chemical Biology","year":2021,"id":619369,"datarank":0.37273599746820013,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.0,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1598314,"name":"Takaaki Taguchi","orcid":null,"position":1,"is_corresponding":false},{"id":348655,"name":"Huili Wang","orcid":"0000-0002-6851-3529","position":2,"is_corresponding":false},{"id":1598315,"name":"Megumi Yuki","orcid":null,"position":3,"is_corresponding":false},{"id":778887,"name":"Megumi Tanaka","orcid":null,"position":4,"is_corresponding":false},{"id":1598316,"name":"Kai Gong","orcid":null,"position":5,"is_corresponding":false},{"id":1380743,"name":"Jinghua Xu","orcid":"0000-0002-0036-8900","position":6,"is_corresponding":false},{"id":351542,"name":"Yiming Zhao","orcid":"0000-0003-1801-9343","position":7,"is_corresponding":false},{"id":1598317,"name":"Koji Ichinose","orcid":null,"position":8,"is_corresponding":false},{"id":1107773,"name":"Aiying Li","orcid":"0000-0002-6732-921X","position":9,"is_corresponding":false},{"id":734178,"name":"Xiaofeng Cai","orcid":"0000-0001-7274-017X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Identification of a <i>C</i>-Glycosyltransferase Involved in Medermycin Biosynthesis","abstract":"C -Glycosylation in the biosynthesis of bioactive natural products is quite unique, which has not been studied well. Medermycin, as an antitumor agent in the family of pyranonaphthoquinone antibiotics, is featured with unique C -glycosylation. Here, a new C -glycosyltransferase ( C -GT) Med-8 was identified to be essential for the biosynthesis of medermycin, as the first example of C -GT to recognize a rare deoxyaminosugar (angolosamine). med -8 and six genes ( med -14, -15, -16, -17, -18, and -20 located in the medermycin biosynthetic gene cluster) predicted for the biosynthesis of angolosamine were proved to be functional and sufficient for C -glycosylation. A C -glycosylation cassette composed of these seven genes could convert a proposed substrate into a C -glycosylated product. In conclusion, these genes involved in the C -glycosylation of medermycin were functionally identified and biosynthetically engineered, and they provided the possibility of producing new C -glycosylated compounds.","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34080843","pmcid":null,"openalex_id":"https://openalex.org/W3164282703","authors":[],"funders":[{"funder_name":"State Administration of Foreign Experts Affairs","grant_id":"B16030","title":null},{"funder_name":"State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology","grant_id":"KF201825","title":null},{"funder_name":"Ministry of Science and Technology of the People's Republic of China","grant_id":"2018YFA0900400","title":null},{"funder_name":"Ministry of Science and Technology of the People's Republic of China","grant_id":"2019YFA0905700","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"30800020","title":null},{"funder_name":"National Natural Science Foundation of China","grant_id":"31170050","title":null},{"funder_name":"Natural Science Foundation of Shandong Province","grant_id":"ZR2017MC031","title":null}],"total_grants":7,"fwci":1.3586,"citation_percentile":0.7923763,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":3},{"year":2023,"count":3},{"year":2024,"count":2},{"year":2025,"count":2}],"oa_status":"closed","license":"https://doi.org/10.15223/policy-029","oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/acschembio.1c00227","host_type":"publisher"},{"url":"https://doi.org/10.1021/acschembio.1c00227","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34080843","host_type":"repository"}],"fields_of_study":["Microbial Natural Products and Biosynthesis","Bioactive Compounds and Antitumor Agents","Carbohydrate Chemistry and Synthesis","Bacterial Proteins","Biosynthetic Pathways","Genes, Bacterial","Glycosyltransferases","Models, Molecular","Multigene Family","Naphthoquinones","Phylogeny","Streptomyces","Benzoisochromanequinones"],"mesh_terms":["Benzoisochromanequinones","Bacterial Proteins","Genes, Bacterial","Multigene Family","Models, Molecular","Naphthoquinones","Phylogeny","Streptomyces","Glycosyltransferases","Biosynthetic Pathways"],"keywords":["Glycosylation","Glycosyltransferase","Biosynthesis","Gene cluster","Gene","Biochemistry","Biology","Natural product","Chemistry"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T06:54:28.346874Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}