{"doi":"10.1021/acsbiomaterials.2c01482","title":"Bioorthogonal “Click Chemistry” Bone Cement with Bioinspired Natural Mimicking Microstructures for Bone Repair","abstract":"Current bone cement systems often demand free radical or metal-related initiators and/or catalysts for the crosslinking process, which may cause serious toxicity to the human body. In addition, the resultant dense scaffolds may have a prolonged degradation time and are difficult for cells to infiltrate and form new tissue. In this study, we developed a porous “click” organic–inorganic nanohybrid (PO-click-ON) cement that crosslinks via metal-free biorthogonal click chemistry and forms porous structures mimicking the native bone tissue via particulate leaching. Strain-promoted click reaction enables fast and efficient crosslinking of polymer chains with the exclusion of any toxic initiator or catalyst. The resulting PO-click-ON implants supported exceptional in vitro stem cell adhesion and osteogenic differentiation with a large portion of stem cells infiltrated deep into the scaffolds. In vivo study using a rat cranial defect model demonstrated that the PO-click-ON system achieved outstanding cell adsorption, neovascularization, and bone formation. The porous click cement developed in this study serves as a promising platform with multifunctionality for bone and other tissue engineering applications.","journal":"ACS Biomaterials Science & Engineering","year":2023,"id":357317,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9552,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":283284,"name":"Bipin Gaihre","orcid":null,"position":1,"is_corresponding":false},{"id":283285,"name":"Linli Li","orcid":null,"position":2,"is_corresponding":false},{"id":530455,"name":"Asghar Rezaei","orcid":"0000-0003-1129-7412","position":3,"is_corresponding":false},{"id":661821,"name":"Maryam Tilton","orcid":"0000-0003-4495-5813","position":4,"is_corresponding":false},{"id":381139,"name":"Benjamin D. Elder","orcid":"0000-0002-7782-7829","position":5,"is_corresponding":false},{"id":280847,"name":"Lichun Lu","orcid":"0000-0002-3862-6493","position":6,"is_corresponding":false},{"id":280842,"name":"Xifeng Liu","orcid":"0000-0002-2684-6309","position":0,"is_corresponding":true}],"reference_count":64,"raw_metadata":null,"created_at":"2026-07-19T01:13:34.795336Z","pmid":"36854041","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}