{"doi":"10.1021/acsbiomaterials.2c00640","title":"Hydrogel Injection Molding to Generate Complex Cell Encapsulation Geometries","abstract":null,"journal":"ACS Biomaterials Science & Engineering","year":2022,"id":676825,"datarank":0.515098080672772,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"self_citation_contribution":0.515098080672772,"citation_network_contribution":0.0,"self_endowment_contribution":0.515098080672772,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":799939,"name":"Alec B. McCall","orcid":"0000-0002-5408-6204","position":1,"is_corresponding":false},{"id":659928,"name":"Sarah R. Brady","orcid":"0000-0002-4348-4979","position":2,"is_corresponding":false},{"id":275700,"name":"Emily M. Slaby","orcid":"0000-0002-1853-2545","position":3,"is_corresponding":false},{"id":294504,"name":"Jessica D. Weaver","orcid":"0000-0001-7394-2443","position":4,"is_corresponding":false},{"id":436377,"name":"Amy E. Emerson","orcid":"0000-0003-0209-3717","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Hydrogel Injection Molding to Generate Complex Cell Encapsulation Geometries","abstract":"Biofabrication methods capable of generating complex, three-dimensional, cell-laden hydrogel geometries are often challenging technologies to implement in the clinic and scaled manufacturing processes. Hydrogel injection molding capitalizes on the reproducibility, efficiency, and scalability of the injection molding process, and we adapt this technique to biofabrication using a library of natural and synthetic hydrogels with varied crosslinking chemistries and kinetics. We use computational modeling to evaluate hydrogel library fluid dynamics within the injection molds in order to predict molding feasibility and cytocompatibility. We evaluate the reproducibility of hydrogel construct molding and extraction and establish criteria for the selection of hydrogels suitable for injection molding. We demonstrate that hydrogel injection molding is capable of generating complex three-dimensional cell-laden construct geometries using diverse hydrogel materials and that this platform is compatible with primary human islet encapsulation. These results highlight the versatility and feasibility of hydrogel injection molding as a biofabrication technique with potential applications in the clinic and biomanufacturing.","is_dataset_classified":null,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36044604","pmcid":null,"openalex_id":"https://openalex.org/W4293820894","authors":[],"funders":[{"funder_name":"Juvenile Diabetes Research Foundation","grant_id":"1-INO-2020-915-A-N","title":null},{"funder_name":"National Institutes of Health","grant_id":"1S10RR027154-01A1","title":"Acquisition of a Leica TCS SP5 Laser Scanning Confocal Microscope"},{"funder_name":"Arizona Biomedical Research Commission","grant_id":"","title":null}],"total_grants":3,"fwci":2.2218,"citation_percentile":0.87602182,"influential_citations":0,"citation_trend":[{"year":2023,"count":6},{"year":2024,"count":10},{"year":2025,"count":12},{"year":2026,"count":2}],"oa_status":"closed","license":"STM Policy #29","oa_locations":[{"url":"https://pubs.acs.org/doi/pdf/10.1021/acsbiomaterials.2c00640","host_type":"publisher"},{"url":"https://doi.org/10.1021/acsbiomaterials.2c00640","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36044604","host_type":"repository"},{"url":"https://doi.org/10.1101/2021.10.31.466681","host_type":""},{"url":"https://www.biorxiv.org/content/biorxiv/early/2021/11/03/2021.10.31.466681.full.pdf","host_type":""},{"url":"https://dx.doi.org/10.1101/2021.10.31.466681","host_type":""}],"fields_of_study":["3D Printing in Biomedical Research","Additive Manufacturing and 3D Printing Technologies","Innovative Microfluidic and Catalytic Techniques Innovation","0301 basic medicine","0303 health sciences","03 medical and health sciences","Cell Encapsulation","Humans","Hydrogels","Injections","Reproducibility of Results"],"mesh_terms":["Cell Encapsulation","Humans","Injections","Reproducibility of Results","Hydrogels"],"keywords":["Biofabrication","Self-healing hydrogels","Molding (decorative)","Materials science","Cell encapsulation","Nanotechnology","Biomanufacturing","Encapsulation (networking)","Biomedical engineering","Computer science","Tissue engineering","Composite material","Engineering","Biotechnology","hydrogels","Humans","Reproducibility of Results","Injections"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T03:10:21.735706Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}